286947-03-3

Basic information

• Product Name: 5-BROMO-2-CHLORO-3-METHOXYPYRIDINE
• Synonyms: 5-BROMO-2-CHLORO-3-METHOXYPYRIDINE;2-CHLORO-3-METHOXY-5-BROMOPYRIDINE
• CAS NO: 286947-03-3
• Molecular Formula: C₆H₅BrClNO
• Molecular Weight: 222.47
• Mol File: 286947-03-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 68-72°C
• Boiling Point: 245.617 °C at 760 mmHg
• Flash Point: 102.346 °C
• Appearance: /
• Density: 1.65 g/cm³
• Vapor Pressure: 0.045mmHg at 25°C
• Refractive Index: 1.56
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -3.02±0.10(Predicted)
• CAS DataBase Reference: 5-BROMO-2-CHLORO-3-METHOXYPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-CHLORO-3-METHOXYPYRIDINE(286947-03-3)
• EPA Substance Registry System: 5-BROMO-2-CHLORO-3-METHOXYPYRIDINE(286947-03-3)

Safety Data

• Hazard Codes: Xn,T
• Statements: 22-41-25
• Safety Statements: 26-39-45
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 286947-03-3(Hazardous Substances Data)

Usage

General Description

5-Bromo-2-chloro-3-methoxypyridine is a chemical compound with the molecular formula C6H5BrClNO. It is a pyridine derivative with a bromo, chloro, and methoxy group attached to the pyridine ring. 5-BROMO-2-CHLORO-3-METHOXYPYRIDINE is commonly used as a building block in organic synthesis for the production of pharmaceuticals, agrochemicals, and other fine chemicals. It is also used as an intermediate in the manufacturing of various products, including insecticides and herbicides. Additionally, 5-Bromo-2-chloro-3-methoxypyridine has been studied for its potential biological and pharmacological activities, making it an important compound in the field of medicinal chemistry.

InChI:InChI=1/C6H5BrClNO/c1-10-5-2-4(7)3-9-6(5)8/h2-3H,1H3

Upstream product

• 74115-13-2 5-bromopyridine-3-ol 
• 74-88-4 methyl iodide 

Downstream Products

• 947688-87-1 2-(5-bromo-3-methoxypyridin-2-yl)acetonitrile 
• 944805-60-1 5-bromo-2-iodo-3-methoxy-pyridine 
• 952059-92-6 methyl 2-[3-methoxy-5-(7-ethoxy-1,5-naphthyridin-4-yloxy)pyridin-2-yl]acetate 
• 952059-87-9 methyl 2-[3-methoxy-5-(6-methoxy-1,5-naphthyridin-4-yloxy)pyridin-2-yl]acetate 
• 952059-89-1 methyl 2-[3-methoxy-5-(7-methoxy-1,5-naphthyridin-4-yloxy)pyridin-2-yl]acetate 
• 1241752-31-7 2-ethoxy-3-methoxy-5-bromopyridine 

Relevant articles and documents

AROMATIC RING COMPOUND

The present invention provides an aromatic ring compound having a melanin-concentrating hormone receptor antagonistic action and useful as an agent for the prophylaxis or treatment of obesity and the like. The present invention relates to a compound represented by the formula wherein each symbol as defined in the specification, or a salt thereof.

Structure-activity studies and analgesic efficacy of N-(3-pyridinyl)- bridged bicyclic diamines, exceptionally potent agonists at nicotinic acetylcholine receptors

A series of exceptionally potent agonists at neuronal nicotinic acetylcholine receptors (nAChRs) has been investigated. Several N-(3-pyridinyl) derivatives of bridged bicyclic diamines exhibit double-digit-picomolar binding affinities for the α4β2 subtype, placing them with epibatidine among the most potent nAChR ligands described to date. Structure-activity studies have revealed that substitutions, particularly hydrophilic groups in the pyridine 5-position, differentially modulate the agonist activity at ganglionic vs central nAChR subtypes, so that improved subtype selectivity can be demonstrated in vitro. Analgesic efficacy has been achieved across a broad range of pain states, including rodent models of acute thermal nociception, persistent pain, and neuropathic allodynia. Unfortunately, the hydrophilic pyridine substituents that were shown to enhance agonist selectivity for central nAChRs in vitro tend to limit CNS penetration in vivo, so that analgesic efficacy with an improved therapeutic window was not realized with those compounds.