444731-73-1

Basic information

• Product Name: 2,3-DIMETHYL-6-NITRO-2H-INDAZOLE
• Synonyms: 2,3-DIMETHYL-6-NITRO-2H-INDAZOLE;2,3-dimethyl-6-nitro-1H-indazole;2,3-Dimethyl-6-nitro-1H-i...;2H-Indazole, 2,3-diMethyl-6-nitro-;3-Methly-6-nitroindazole;3-diMethyl-6-nitro-2H-indazole;Pazopanib Impurity 5
• CAS NO: 444731-73-1
• Molecular Formula: C₉H₉N₃O₂
• Molecular Weight: 191.19
• EINECS: 1592732-453-0
• Mol File: 444731-73-1.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 377.033°C at 760 mmHg
• Flash Point: 181.824°C
• Appearance: /
• Density: 1.37g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.655
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: -0.55±0.30(Predicted)
• CAS DataBase Reference: 2,3-DIMETHYL-6-NITRO-2H-INDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIMETHYL-6-NITRO-2H-INDAZOLE(444731-73-1)
• EPA Substance Registry System: 2,3-DIMETHYL-6-NITRO-2H-INDAZOLE(444731-73-1)

Safety Data

• Hazardous Substances Data: 444731-73-1(Hazardous Substances Data)

Usage

Description

2,3-DIMETHYL-6-NITRO-2H-INDAZOLE is an organic compound that serves as an impurity in the synthesis of Pazopanib (P210925) hydrochloride, which is an oral angiogenesis inhibitor targeting VEGFR and PDGFR.

Uses

Used in Pharmaceutical Industry:
2,3-DIMETHYL-6-NITRO-2H-INDAZOLE is used as an impurity in the synthesis of Pazopanib (P210925) hydrochloride for its role in targeting VEGFR and PDGFR, which are essential in the development of various types of cancer. Its presence in the synthesis process may affect the efficacy and safety of the final drug product, making it a significant consideration in the development and production of Pazopanib hydrochloride.

InChI:InChI=1/C9H9N3O2/c1-6-8-4-3-7(12(13)14)5-9(8)10-11(6)2/h3-5H,1-2H3

Downstream Products

• 444731-75-3 N-(2-chloropyrimidin-4-yl)-N-methyl-2,3-dimethyl-2H-indazole-6-amine 
• 635702-64-6 pazopanib hydrochloride 
• 444731-52-6 pazopanib 
• 1376676-65-1 N,2,3-trimethyl-2H-indazole-6-amine 
• 1620059-11-1 5-[[4-[N-(2,3-dimethyl-2H-indazol-6-yl)-N-methylamino]-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl]amino]-2-methyl-benzenesulfonamide 
• 1620843-77-7 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)amino]-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl]amino]-2-methyl-benzenesulfonamide 
• 1620059-12-2 3-[[4-[N-(2,3-dimethyl-2H-indazol-6-yl)-N-methylamino]-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl]amino]-benzenesulfonamide 
• 1620843-78-8 3-[[4-[(2,3-dimethyl-2H-indazol-6-yl)amino]-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl]amino]-benzenesulfonamide 
• 1620843-79-9 3-[[4-[N-(2,3-dimethyl-2H-indazol-6-yl)-N-methylamino]-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl]amino]-4-methoxy-benzenesulfonamide 
• 1620059-14-4 N²-(3,4-dimethoxyphenyl)-N⁴-(2,3-dimethyl-2H-indazol-6-yl)-N⁴-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine 
• 1620059-15-5 N²-(3-bromohenyl)-N⁴-(2,3-dimethyl-2H-indazol-6-yl)-N⁴-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine 
• 1620059-16-6 N⁴-(2,3-dimethyl-2H-indazol-6-yl)-N²-(3-fluorohenyl)-N⁴-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine 
• 1620843-80-2 5-[[4-[N-(2,3-dimethyl-2H-indazol-6-yl)-N-methylamino]-5,6,7,8-tetrahydroquinazolin-2-yl]amino]-2-methyl-benzenesulfonamide 
• 1620843-82-4 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)amino]-5,6,7,8-tetrahydroquinazolin-2-yl]amino]-2-methyl-benzenesulfonamide