52532-63-5

Basic information

• Product Name: 5-AMinothiophene-2-carbonitrile
• Synonyms: 5-AMinothiophene-2-carbonitrile;5-amino-2-Thiophenecarbonitrile
• CAS NO: 52532-63-5
• Molecular Formula: C5H4N2S
• Molecular Weight: 124.16366
• Mol File: 52532-63-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 312.1±22.0 °C(Predicted)
• Appearance: /
• Density: 1.33±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: -0.37±0.10(Predicted)
• CAS DataBase Reference: 5-AMinothiophene-2-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMinothiophene-2-carbonitrile(52532-63-5)
• EPA Substance Registry System: 5-AMinothiophene-2-carbonitrile(52532-63-5)

Safety Data

• Hazardous Substances Data: 52532-63-5(Hazardous Substances Data)

Usage

General Description

5-Aminothiophene-2-carbonitrile is a chemical compound with the molecular formula C5H4N2S. It is a heterocyclic compound that contains a thiophene ring with an amino group and a nitrile group attached to it. 5-AMinothiophene-2-carbonitrile is commonly used in the synthesis of pharmaceuticals, agrochemicals, and materials. It has also been studied for its potential biological activities, such as antimicrobial and antiviral properties. 5-Aminothiophene-2-carbonitrile is a versatile building block in organic synthesis, and its unique structure makes it a valuable component in the development of diverse chemical compounds for various industrial and scientific applications.

Upstream product

• 603130-87-6 N-(t-butoxycarbonyl)-5-aminothiophene-2-carbonitrile 
• 16689-02-4 5-nitro-2-thienyl cyanide 

Relevant articles and documents

MODIFIED PROTEINS AND PROTEIN DEGRADERS

Provided herein are compounds, pharmaceutical compositions, and methods for binding or degrading target proteins. Further provided herein are compounds having a DNA damage-binding protein 1 (DDB1) binding moiety. Some such embodiments include a linker. Some such embodiments include a target protein binding moiety. Further provided herein are ligand-DDB1 complexes. Further provided herein are in vivo modified DDB1 proteins.

METHOD FOR THE PREPARATION OF FUSED HETEROCYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF

Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.

2-Aminothiabutadiene as useful building block in the synthesis of 2-aminothiopyrans and 2-aminothiophenes

We report a reliable and regiocontrolled alternative route to unsubstituted 2-aminothiopyrans and 2-aminothiophenes. These sulfur heterocycles were prepared by reaction of protected aminothiabutadiene 1 with acrylic dienophiles or acceptor-substituted halomethyl compounds. All compounds were fully characterized by IR, HRMS, and 13C and 1H NMR spectroscopy.