59936-29-7Relevant articles and documents
Tetrahydropyrido [3, 4-d] pyrimidine derivative and medical application thereof
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Paragraph 0273; 0277; 0319-0323, (2021/03/06)
The invention relates to a compound as shown in a general formula (I) or a stereoisomer, a deuterated compound, a solvate, a prodrug, a metabolite, a pharmaceutically acceptable salt or eutectic crystal thereof, an intermediate and a preparation method thereof, and application of the compound in preparation of drugs for treating diseases related to KRas-G12C activity or expression quantity.
METHODS OF TREATING PAINFUL DIABETIC PERIPHERAL NEUROPATHY
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Paragraph 0164-0166, (2021/05/14)
Provided herein are methods of treating painful diabetic peripheral neuropathy, such as advanced painful DPN, in a patient by administering to the patient an effective amount of NYX-2925 or a pharmaceutically acceptable salt thereof. Also provided are crystalline forms of 3-hydroxy-2-(5-isobutyryl-1-oxo-2,5-diazaspiro[3,4]octan-2-yl)butanamide.
Direct Amidation of Esters by Ball Milling**
Nicholson, William I.,Barreteau, Fabien,Leitch, Jamie A.,Payne, Riley,Priestley, Ian,Godineau, Edouard,Battilocchio, Claudio,Browne, Duncan L.
supporting information, p. 21868 - 21874 (2021/09/02)
The direct mechanochemical amidation of esters by ball milling is described. The operationally simple procedure requires an ester, an amine, and substoichiometric KOtBu and was used to prepare a large and diverse library of 78 amide structures with modest to excellent efficiency. Heteroaromatic and heterocyclic components are specifically shown to be amenable to this mechanochemical protocol. This direct synthesis platform has been applied to the synthesis of active pharmaceutical ingredients (APIs) and agrochemicals as well as the gram-scale synthesis of an active pharmaceutical, all in the absence of a reaction solvent.