61925-78-8 Usage
Description
BOC-D-CYS(MBZL)-OH, also known as Boc-D-Cysteine 4-Methoxybenzyl Ester, is a synthetic derivative of the naturally occurring amino acid cysteine. It is characterized by the presence of a 4-methoxybenzyl (Mbzl) protecting group and a tert-butyloxycarbonyl (BOC) group, which are commonly used in peptide synthesis to protect the thiol group and the amino group, respectively. BOC-D-CYS(MBZL)-OH is a white powder and is widely utilized in the field of chemical synthesis and peptide chemistry due to its unique structural features and reactivity.
Uses
Used in Chemical Synthesis:
BOC-D-CYS(MBZL)-OH is used as a building block in chemical synthesis for the preparation of various complex organic molecules, including pharmaceuticals, agrochemicals, and other specialty chemicals. The BOC and Mbzl protecting groups facilitate the selective introduction of the D-cysteine residue into target molecules, allowing for the controlled formation of desired products.
Used in Peptide Chemistry:
In peptide chemistry, BOC-D-CYS(MBZL)-OH is employed as a protected amino acid for the solid-phase synthesis of peptides containing D-cysteine. The BOC group protects the amino group from side reactions, while the Mbzl group shields the thiol group, preventing disulfide bond formation and oxidation during the synthesis process. This allows for the stepwise assembly of peptide chains with precise control over the sequence and structure.
Used in Pharmaceutical Research:
BOC-D-CYS(MBZL)-OH is used as a key intermediate in the development of novel therapeutic agents, particularly in the design and synthesis of peptide-based drugs. BOC-D-CYS(MBZL)-OH's unique structural features enable the creation of peptides with enhanced stability, bioavailability, and target specificity, making it a valuable tool in the search for new treatments for various diseases.
Used in Drug Delivery Systems:
In the field of drug delivery, BOC-D-CYS(MBZL)-OH can be utilized to develop targeted drug delivery systems. BOC-D-CYS(MBZL)-OH's reactivity and structural features can be exploited to design drug conjugates or prodrugs that selectively release the active pharmaceutical ingredient at the site of action, thereby improving the drug's efficacy and reducing side effects.
Used in Biochemical Research:
BOC-D-CYS(MBZL)-OH is also used in biochemical research as a reagent for the study of protein structure, function, and interactions. BOC-D-CYS(MBZL)-OH can be employed to introduce D-cysteine residues into proteins of interest, allowing researchers to investigate the effects of this amino acid on protein folding, stability, and activity.
Check Digit Verification of cas no
The CAS Registry Mumber 61925-78-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,9,2 and 5 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 61925-78:
(7*6)+(6*1)+(5*9)+(4*2)+(3*5)+(2*7)+(1*8)=138
138 % 10 = 8
So 61925-78-8 is a valid CAS Registry Number.
61925-78-8Relevant articles and documents
Combination of non-natural D-amino acid derivatives and allophenylnorstatine-dimethylthioproline scaffold in HIV protease inhibitors have high efficacy in mutant HIV
Nakatani, Shingo,Hidaka, Koushi,Ami, Ei'Ichi,Nakahara, Koichiro,Sato, Akihiko,Nguyen, Jeffrey-Tri,Hamada, Yoshio,Hori, Yasuko,Ohnishi, Nobuyuki,Nagai, Akinori,Kimura, Tooru,Hayashi, Yoshio,Kiso, Yoshiaki
experimental part, p. 2992 - 3004 (2009/04/05)
Several non-natural D-amino acid derivatives were introduced as P2/P3 residues in allophenylnorstatine-containing (Apns; (2S,3S)-3-amino-2-hydroxy-4- phenylbutyric acid) HIV protease inhibitors. The synthetic analogues exhibited potent inhibitory activity
