65040-68-8

Basic information

• Product Name: Pyridine, 1,2,3,6-tetrahydro-4-[3-(trifluoromethyl)phenyl]-
• CAS NO: 65040-68-8
• Molecular Formula: C12H12F3N
• Molecular Weight: 227.229
• Mol File: 65040-68-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Pyridine, 1,2,3,6-tetrahydro-4-[3-(trifluoromethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 1,2,3,6-tetrahydro-4-[3-(trifluoromethyl)phenyl]-(65040-68-8)
• EPA Substance Registry System: Pyridine, 1,2,3,6-tetrahydro-4-[3-(trifluoromethyl)phenyl]-(65040-68-8)

Safety Data

• Hazardous Substances Data: 65040-68-8(Hazardous Substances Data)

Upstream product

• 454228-69-4 tert-butyl-4-(3-trifluoromethylphenyl)-5,6-dihydropyridine-1(2H)-carboxylate 
• 2249-28-7 4-(3-trifluoromethylphenyl)-4-hydroxy piperidine 

Downstream Products

• 454228-70-7 C₁₅H₁₇ClF₃N 
• 473931-99-6 7-(2-(4-(3-(Trifluoromethyl)-phenyl)piperidino)ethyl)isoquinoline 
• 208989-03-1 1-[2-(3-methyl-4-pentylphenyl)ethyl]-4-(3-trifluoromethyl-phenyl)-1,2,3,6-tetrahydropyridine 
• 209159-20-6 1-[2,2-(4,4'-dichlorodiphenyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine 
• 759456-39-8 7-(2-(4-(3-trifluoromethylphenyl)piperazin-1-yl)-ethyl)isoquinoline 

Relevant articles and documents

Design, synthesis, and evaluation of novel aryl-tetrahydropyridine PPARα/γ dual agonists

Aryl-tetrahydropyridine derivatives were prepared and their PPARα/γ dual agonistic activities were evaluated. Among them, compound (S)-5b was identified as a potent PPARα/γ dual agonist with an EC50 of 1.73 and 0.64 μM in hPPARα and γ, respectively. In diabetic (db/db) mice, compound (S)-5b showed good glucose lowering efficacy and favorable pharmacokinetic properties.

Piperidine derivatives having renin inhibiting activity

Novel piperidine derivatives, their manufacture and use as medicaments, are disclosed. The invention is concerned with the novel piperidine derivatives of general formula I wherein R1, R2, R3, R4, Q, X, Z, m and n are as described herein.