68856-96-2Relevant articles and documents
Synthesis of unit-B of cryptophycin-24 via Sharpless asymmetric dihydroxylation
Borah, Arun Jyoti,Goswami, Progyashree,Barua, Nabin C.,Phukan, Prodeep
, p. 7128 - 7130 (2013/01/15)
A synthetic pathway for the synthesis of unit-B of cryptophycin-24 has been developed using Sharpless asymmetric dihydroxylation as the key step. This study shows that direct azidation of α-hydroxy acid ester using diphenylphosphoryl azide is beneficial to asymmetric synthesis of α-amino acid without the loss of chirality during the transformation.
Heterocyclic derivatives and their use as antithrombotic agents
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, (2008/06/13)
The present invention relates to antithrombotic compounds comprising the group Q, Q having formula (I), wherein the substructure (i) is a structure selected from (a, b and c), wherein X is O or S; X′ being independently CH or N; and m is 0, 1, 2 or 3; wherein the group Q is bound through an oxygen atom or an optionally substituted nitrogen or carbon atom, or a pharmaceutically acceptable salt thereof or a prodrug thereof. The compounds of the invention are therapeutically active and in particular are antithrombotic agents.