75091-93-9

Basic information

• Product Name: trans-4-(Trifluoromethyl)cyclohexanol
• Synonyms: trans-4-(Trifluoromethyl)cyclohexanol;trans (e,e)-4-trifluoromethylcyclohexanol;trans-4-(Trifluoromethyl)
• CAS NO: 75091-93-9
• Molecular Formula: C₇H₁₁F₃O
• Molecular Weight: 168.1568496
• Mol File: 75091-93-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 160.4±35.0 °C(Predicted)
• Appearance: /
• Density: 1.231±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 14.88±0.40(Predicted)
• CAS DataBase Reference: trans-4-(Trifluoromethyl)cyclohexanol(CAS DataBase Reference)
• NIST Chemistry Reference: trans-4-(Trifluoromethyl)cyclohexanol(75091-93-9)
• EPA Substance Registry System: trans-4-(Trifluoromethyl)cyclohexanol(75091-93-9)

Safety Data

• Hazardous Substances Data: 75091-93-9(Hazardous Substances Data)

Usage

General Description

Trans-4-(Trifluoromethyl)cyclohexanol is a chemical compound with the molecular formula C7H11F3O. It is a colorless liquid with a slightly sweet odor. trans-4-(Trifluoromethyl)cyclohexanol is used as a solvent, intermediate, and reagent in organic synthesis. It is also utilized in the production of pharmaceuticals and agrochemicals. Additionally, trans-4-(Trifluoromethyl)cyclohexanol is an important building block in the synthesis of various fluorinated compounds, which have applications in the pharmaceutical and agricultural industries. trans-4-(Trifluoromethyl)cyclohexanol is considered to be of low toxicity, but caution should be exercised when handling it, as prolonged exposure may cause irritation to the skin, eyes, and respiratory system.

Upstream product

• 402-45-9 4-hydroxybenzotrifluoride 
• 75091-99-5 4-(trifluoromethyl)cyclohexan-1-one 
• 401-75-2 trifluoromethylcyclohexane 
• 343217-50-5 Trifluoro-acetic acid 4-trifluoromethyl-cyclohexyl ester 

Downstream Products

• 75091-99-5 4-(trifluoromethyl)cyclohexan-1-one 
• 133261-24-2 trans-4-trifluoromethylcyclohexyl trans-4-pentylcyclohexanecarboxylate 
• 1400916-98-4 C₁₅H₉F₆N₃O₃ 
• 1544663-58-2 5-iodo-2-methyl-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)quinoline 
• 1544663-95-7 6-bromo-1-iodo-2-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene 
• 1544663-98-0 6-bromo-1-(trifluoromethyl)-2-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene 
• 1544664-00-7 methyl 5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)-2-naphthoate 
• 1544664-03-0 5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)-2-naphthoic acid 
• 1544010-47-0 trans-4-(trifluoromethyl)cyclohexyl methanesulfonate 
• 1544010-54-9 cis-4-(trifluoromethyl)cyclohexyl methanesulfonate 
• 1544665-15-7 2-bromo-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene 
• 1548149-96-7 2-bromo-6-((trans-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene 

Relevant articles and documents

Method for synthesizing cis-trifluoromethylcyclohexane derivatives and heterocyclic compounds by hydrogenation

The invention discloses a method for synthesizing cis-trifluoromethylcyclohexane derivatives and heterocyclic compounds by hydrogenation. The method is characterized in that trifluoromethylaromatic hydrocarbons or trifluoromethyl heterocyclic compounds ar

Hydrogen-free ring hydrogenation of phenol to cyclohexanol over a rhodium-loaded titanium(IV) oxide photocatalyst

Since photocatalytic reactions are almost consistent with the concept of green chemistry, substance conversion using photocatalysts has recently attracted the attention of researchers in the fields of organic chemistry, physical chemistry and material chemistry. We investigated photoinduced ring hydrogenation of phenol over a metal-loaded titanium(IV) oxide (TiO2) photocatalyst without the use of H2 gas and we report here the effects of various parameters, including the type and amount of metal co-catalyst loaded on TiO2 and the kinds of solvents and hole scavengers, on the ring hydrogenation. We found that the combination of an Rh co-catalyst, water and oxalic acid resulted in the highest yield of cyclohexanol. Detailed analyses revealed that phenol was first hydrogenated to cyclohexanone via keto-enol tautomerism of cyclohexenol followed by hydrogenation of cyclohexanone to cyclohexanol and that adsorption of phenol onto Rh-TiO2 is a factor of great importance for the ring hydrogenation.

MELANOCORTIN RECEPTOR AGONISTS

The present invention relates to a compound of the following formula 1, pharmaceutically acceptable salt and isomer thereof effective as agonist of melanocortin receptor, and an agonistic composition of melanocortin receptor comprising the same as active ingredient.