858854-82-7

Basic information

• Product Name: 3-CHLORO-2-IODOPHENOL
• Synonyms: 3-CHLORO-2-IODOPHENOL;3-Choro-2-iodophenol
• CAS NO: 858854-82-7
• Molecular Formula: C₆H₄ClIO
• Molecular Weight: 254.45
• Product Categories: pharmacetical
• Mol File: 858854-82-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 56 °C
• Boiling Point: 225.6°C at 760 mmHg
• Flash Point: 90.2°C
• Appearance: /
• Density: 2.087g/cm³
• Vapor Pressure: 0.0572mmHg at 25°C
• Refractive Index: 1.677
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 7.55±0.10(Predicted)
• CAS DataBase Reference: 3-CHLORO-2-IODOPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-2-IODOPHENOL(858854-82-7)
• EPA Substance Registry System: 3-CHLORO-2-IODOPHENOL(858854-82-7)

Safety Data

• Hazardous Substances Data: 858854-82-7(Hazardous Substances Data)

Usage

General Description

3-Chloro-2-iodophenol is a chemical compound with the molecular formula C6H4ClIO. It is a derivative of phenol and contains both chlorine and iodine atoms. 3-CHLORO-2-IODOPHENOL is mainly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It can also be used as a starting material for the preparation of other organic compounds. 3-Chloro-2-iodophenol has potential applications in the field of medicinal chemistry and material science due to its unique chemical properties and reactivity. It is important to handle this compound with caution and in accordance with safety guidelines due to its potential toxicity and harmful effects on human health and the environment.

InChI:InChI=1/C6H4ClIO/c7-4-2-1-3-5(9)6(4)8/h1-3,9H

Upstream product

• 108-43-0 3-monochlorophenol 
• 91105-99-6 1-chloro-3-(methoxymethoxy)benzene 
• 2845-89-8 1-chloro-3-methoxy-benzene 
• 791642-67-6 1-chloro-2-iodo-3-methoxybenzene 
• 159390-33-7 3-chlorophenyl N,N-diethylcarbamate 
• 863870-77-3 3-chloro-2-iodophenyl N,N-dimethyl O-carbamate 
• 56962-00-6 2-amino-3-chlorophenol 

Downstream Products

• 945470-02-0 tert-butyl 2-(3-chloro-2-iodophenoxy)acetate 
• 945470-03-1 3-chloro-2-iodo-1-triisopropylsilyloxybenzene 
• 791642-67-6 1-chloro-2-iodo-3-methoxybenzene 
• 945470-01-9 1-chloro-2-iodo-3-(phenylmethoxy)benzene 
• 1287791-66-5 2-(3-chloro-2-iodophenoxy)-2-methylpropanamide 
• 25235-85-2 4-chloro-1H-indole 
• 70237-25-1 3-chloro-2-iodobenzenamine 
• 108-42-9 3-chloro-aniline 
• 1244651-45-3 N-(3-chloro-2-(hex-1-ynyl)phenyl)-2-hydroxy-2-methylpropanamide 
• 1244651-49-7 N-(3-chloro-2-(hept-1-ynyl)phenyl)-2-hydroxy-2-methylpropanamide 
• 1244651-54-4 N-(3-chloro-2-(2-(trimethylsilyl)ethynyl)phenyl)-2-hydroxy-2-methylpropanamide 
• 1244652-07-0 4-chloro-2-(3-chlorophenyl)-1H-indole 
• 1244651-34-0 N-(3-chloro-2-iodophenyl)-2-hydroxy-2-methylpropanamide 
• 1287792-07-7 2-butyl-4-chloro-3-(phenylthio)-1H-indole 

Relevant articles and documents

KINASE INHIBITOR

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Approaches to the synthesis of 2,3-dihaloanilines. Useful precursors of 4-functionalized-1 H-indoles

2,3-Dihaloanilines have been proved as useful starting materials for synthesizing 4-halo-1H-indoles. Subsequent or in situ functionalization of the prepared haloindoles allows the access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles in good overall yields. As no efficient synthetic routes to 2,3-dihaloanilines have been described in the literature, different approaches to the preparation of these 1,2,3-functionalized aromatic precursors are now presented. The most general one involves a Smiles rearrangement from the corresponding 2,3-dihalophenols and allows the preparation of 2,3-dihaloanilides in a straightforward and synthetically useful manner.

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