916420-27-4

Basic information

• Product Name: TERT-BUTYL 2,4-DICHLORO-5,6-DIHYDROPYRIDO[3,4-D]PYRIMIDINE-7(8H)-CARBOXYLATE
• Synonyms: tert-Butyl 2,4-dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-7-carboxylate 7-Boc-2,4-dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine;tert-butyl 2,4-dichloro-5H,6H,7H,8H-pyrido[3,4-d]pyrimidine-7-carboxylate;tert-butyl 2,4-dichloro-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxylate;TERT-BUTYL 2,4-DICHLORO-5,6-DIHYDROPYRIDO[3,4-D]PYRIMIDINE-7(8H)-CARBOXYLATE;7-Boc-2,4-dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine;tert-Butyl 2,4-dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-7-carboxylate;2,4-Dichloro-7-Boc-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine;7-Boc-2,4-dichloro-5,6,7,...
• CAS NO: 916420-27-4
• Molecular Formula: C₁₂H₁₅Cl₂N₃O₂
• Molecular Weight: 304.1724
• EINECS: 1533716-785-6
• Product Categories: Heterocycle-Pyrimidine series;CHIRAL CHEMICALS
• Mol File: 916420-27-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 423.1 °C at 760 mmHg
• Flash Point: 209.7 °C
• Appearance: /
• Density: 1.352 g/cm³
• Vapor Pressure: 2.3E-07mmHg at 25°C
• Refractive Index: 1.56
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.95±0.20(Predicted)
• CAS DataBase Reference: TERT-BUTYL 2,4-DICHLORO-5,6-DIHYDROPYRIDO[3,4-D]PYRIMIDINE-7(8H)-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 2,4-DICHLORO-5,6-DIHYDROPYRIDO[3,4-D]PYRIMIDINE-7(8H)-CARBOXYLATE(916420-27-4)
• EPA Substance Registry System: TERT-BUTYL 2,4-DICHLORO-5,6-DIHYDROPYRIDO[3,4-D]PYRIMIDINE-7(8H)-CARBOXYLATE(916420-27-4)

Safety Data

• Hazardous Substances Data: 916420-27-4(Hazardous Substances Data)

Usage

Description

TERT-BUTYL 2,4-DICHLORO-5,6-DIHYDROPYRIDO[3,4-D]PYRIMIDINE-7(8H)-CARBOXYLATE is a chemical compound that serves as an intermediate in the synthesis of various organic compounds. It is characterized by its unique molecular structure, which includes a tert-butyl group, a 2,4-dichlorophenyl ring, and a tetrahydropyrido[3,4-d]pyrimidine core. TERT-BUTYL 2,4-DICHLORO-5,6-DIHYDROPYRIDO[3,4-D]PYRIMIDINE-7(8H)-CARBOXYLATE is commonly used in laboratory research and development for the creation of new pharmaceuticals and other chemical products.

Uses

Used in Pharmaceutical Industry:
TERT-BUTYL 2,4-DICHLORO-5,6-DIHYDROPYRIDO[3,4-D]PYRIMIDINE-7(8H)-CARBOXYLATE is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique molecular structure allows it to be a key component in the development of new drugs and medications.
Used in Laboratory Research and Development:
TERT-BUTYL 2,4-DICHLORO-5,6-DIHYDROPYRIDO[3,4-D]PYRIMIDINE-7(8H)-CARBOXYLATE is used as a research tool in laboratories for the development of new chemical compounds and materials. Its versatility and reactivity make it a valuable asset in the synthesis of a wide range of organic compounds.

Synthesis

tert-Butyl 2,4-dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-7-carboxylate can be prepared by Intermediate 4 in DCM stirred with (Boc)2O and TEA at room temperature for 16 hours.

InChI:InChI=1/C12H15Cl2N3O2/c1-12(2,3)19-11(18)17-5-4-7-8(6-17)15-10(14)16-9(7)13/h4-6H2,1-3H3

Upstream product

• 1059735-34-0 7-benzyl-2,4-dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine 
• 62459-02-3 7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2,4(1H,3H)-dione 
• 39514-19-7 ethyl 1-benzyl-3-oxo-4-piperidinecarboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1000578-08-4 2,4-dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine 

Downstream Products

• 1542711-27-2 C₁₉H₂₃ClN₄O₂ 
• 1542708-91-7 C₂₈H₃₁N₅O₂ 
• 1542704-41-5 N-benzyl-2-(2-methyl-1H-indol-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-amine 
• 1542711-32-9 C₁₉H₂₁ClN₄O₃ 
• 1542711-33-0 C₂₅H₂₈N₆O₃ 
• 1542711-38-5 C₂₀H₂₀N₆O 
• 1542710-71-3 4-(benzylamino)-2-(2-methoxy-1H-benzo[d]imidazol-1-yl)-6,7-dihydropyrido[3,4-d]pyrimidin-8(5H)-one 
• 1542704-60-8 1-(4-(benzylamino)-2-(2-methyl-1H-indol-1-yl)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)ethanone 

Relevant articles and documents

FUSED PYRIMIDINES AS INHIBITORS OF p97 COMPLEX

Fused pyrimidine compounds having a saturated, unsaturated or aromatic A ring fused to a pyrimidine ring and having a complex substituents at the 2 position and a substituted amine at the 4 position of the pyrimidine ring as well as optional aliphatic, functional and/or aromatic components substituted at other positions of the pyrimidine ring and A ring are disclosed. These compounds are inhibitors of the AAA proteasome complex containing p97 and are effective medicinal agents for treatment of diseases associated with p97 bioactivity such as cancer.