98266-32-1

Basic information

• Product Name: BOC-D-2-PYRIDYLALANINE
• Synonyms: RARECHEM BK PT 0231;(R)-N-BOC-(2-PYRIDYL)ALANINE;N-ALPHA-T-BOC-BETA-(2-PYRIDYL)-D-ALANINE;N-ALPHA-T-BUTOXYCARBONYL-3-(2-PYRIDYL)-D-ALANINE;N-ALPHA-T-BUTOXYCARBONYL-D-2-PYRIDYLALANINE;N-TERT-BUTOXYCARBONYL-2-PYRIDYL-D-ALANINE;(R)-2-TERT-BUTOXYCARBONYLAMINO-3-PYRIDIN-2-YL-PROPIONIC ACID;BOC-(R)-2-AMINO-3-(2'-PYRIDYL)PROPANOIC ACID
• CAS NO: 98266-32-1
• Molecular Formula: C13H18N2O4
• Molecular Weight: 266.29
• Product Categories: Amino Acids;Phenylalanine analogs and other aromatic alpha amino acids;Amino Acid Derivatives;a-amino
• Mol File: 98266-32-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 145-152 °C
• Boiling Point: 436.9 °C at 760 mmHg
• Flash Point: 218 °C
• Appearance: White powder
• Density: 1.2 g/cm³
• Vapor Pressure: 2.09E-08mmHg at 25°C
• Storage Temp.: Store at 0-5°C
• PKA: 3.09±0.10(Predicted)
• CAS DataBase Reference: BOC-D-2-PYRIDYLALANINE(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-D-2-PYRIDYLALANINE(98266-32-1)
• EPA Substance Registry System: BOC-D-2-PYRIDYLALANINE(98266-32-1)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• HazardClass: IRRITANT
• Hazardous Substances Data: 98266-32-1(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

(αR)?-α-?[[(1,?1-Dimethylethoxy)?carbonyl]?amino]?-?2-pyridinepropanoic Acid is an intermediate used to prepare heterocyclic amides as nitric oxide production inhibitors.

InChI:InChI=1/C13H18N2O4/c1-13(2,3)19-12(18)15-10(11(16)17)8-9-6-4-5-7-14-9/h4-7,10H,8H2,1-3H3,(H,15,18)(H,16,17)/p-1/t10-/m1/s1

Upstream product

• 74164-26-4 N^α-acetyl-β-(2-pyridyl)-L-alanine 
• 185379-37-7 N^α-acetyl-β-(2-pyridyl)-DL-alanine ethyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 98062-70-5 2-amino-3-(pyridin-2-yl)propanoic acid dihydrochloride 
• 109-04-6 2-bromo-pyridine 
• 5029-67-4 2-iodopyridine 
• 55477-80-0 methyl 2-[(tert-butoxycarbonyl)amino]acrylate 
• 19814-60-9 diethyl 2-acetamido-2-(methylpyridin-2-yl)malonate 
• 37535-51-6 (S)-2-amino-3-(pyridin-2-yl)propanoic acid 

Downstream Products

• 553668-09-0 5-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-pyridin-2-yl-propionylamino)-2-pentylcarbamoyl-ethyl]-2-methoxycarbonylmethoxy-benzoic acid methyl ester 

Relevant articles and documents

BICYCLIC COMPOUNDS

Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating cancers. Specific cancers include those that are mediated by YAP/TAZ or those that are modulated by the interaction between YAP/TAZ and TEAD.

Studies on polypeptides XXXII. Solid-phase synthesis of RNase S-peptide 1-14 analogues; replacement of histidine-12 by β-(2-pyridyl)-L-alanine and β-(4-pyridyl)-L-alanine

The synthesis of two analogues of the N-terminal tetradecapeptide of ribonuclease A (RNase S-peptide 1-14), in which the active site histidine-12 residue is replaced by β-(2-pyridyl)-L-alanine and β-(4-pyridyl)-L-alanine, has been accomplished by the solid-phase method.The enantiomers of β-(2-pyridyl)alanine were obtained by chymotryptic hydrolysis of its racemic Nα-acetyl ethyl ester.The Boc derivative of both L-amino acids has been synthesized.