Synthesis p. 792 - 794 (1994)
Update date:2022-09-26
Topics: Characterization Purification Protection of Functional Groups Starting Material De-Protection Formulation Functional Group Modifications Formation of the Prostaglandin Core
Lee
Nam
Jung
Park
An efficient and practical 8-step synthesis of enprostil (1) starting from the lactone 2 has been developed. The propargylic acetate 5 was prepared from the lactol 3 by the reaction with ethynylmagnesium bromide followed by acetylation. Propargylic acetate 5 was converted into enprostil (1) via the introduction of an allene moity by reaction with a Grignard reagent in the presence of a CuI · P(OEt)3 complex.
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Doi:10.1002/hlca.19570400212
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