Journal of Medicinal Chemistry p. 1645 - 1656 (1990)
Update date:2022-08-05
Topics:
Miyamoto, Teruyuki
Matsumoto, Jun-ichi
Chiba, Katsumi
Egawa, Hiroshi
Shibamori, Koh-ichiro
et al.
A series of 5,7-disubstituted 1-cyclopropyl-6,8-difluoro-4(1H)-oxoquinoline-3-carboxylic acids (10-36) were prepared; the C-5 substituent in these compounds comprised halo, hydroxy, mercapto, and amino groups and the C-7 functional group included variously substituted piperazines.In vitro antibacterial screening results indicated that the amino group was optimal among the C-5 substituents.A combination of the C-5 amino group and the C-7 3,5-dimethylpiperazinyl appendage in this series conferred the best overall antibacterial property with lack of adverse drug interactions.Compound 36k
Junkai (Tianjin) Chemical Co., Ltd.
website:http://www.junkaichem.com
Contact:86-22-85689515
Address:Room 8-501, Building K2, The Hi-Tech Green Industrial Base, No.6, 6th Road, Hi-Tech Development Road, Tianjin Hi-Tech IndustrialPark, Tianjin, China.
HEZE KINGVOLT CHEMICAL CO., LTD
Contact:86-573-82118911
Address:Juancheng Industry Park
Contact:
Address:ROOM 1715, No#345 Jin Xiang Road, Pudong District
Beijing Hope Pharmaceutical Co., Ltd.
Contact:86-10-67886402
Address:309,Block 1 District B,No.12 Hongda North Road , Beijing Economic-Technological Development Area, Beijing, China
Hubei Xinghuo Chemical Co., Ltd.,
Contact:13925817279 13907299441
Address:Xinghuo Fine Chemistry Industrial Park, Xiaochang County, Hubei Province, China
Doi:10.1021/acs.orglett.5b00831
(2015)Doi:10.1002/ejic.200701097
(2008)Doi:10.1016/j.tetlet.2009.02.083
(2009)Doi:10.1080/15257770802271771
(2008)Doi:10.1016/j.tet.2008.11.097
(2009)Doi:10.1021/ml300133f
(2012)