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observations clearly indicate that palladium nanopar-
ticles are the catalytically active form of 1.
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Experimental Section
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General Procedure for Suzuki Cross-Coupling
Reactions
In a round-bottom flask at 258C in air were placed the aryl-
boronic acid or potassium trifluoroborate (2.2 mmol), the
aryl bromide (2.0 mmol), an appropriate amount of K2CO3
(2.2 mmol or 7.0 mmol in reactions performed with potassi-
um aryltrifluoroborates; an additional equivalent of base
was added when reactions were performed with substrates
containing OH or COOH groups) and 3.0 mL of n-BuOH/
H2O (9:1). The mixtures were vigorously stirred and heated
up to 1008C. Then 0.1 mL of a 10 mM dioxane (or THF) so-
lution of 1 was added via syringe. Samples were periodically
taken from the reaction mixture, quenched with water, ex-
tracted with ethyl acetate, and analyzed by GC/MS. At the
end of catalysis, the reaction mixtures were allowed to cool
to room temperature, quenched with water, and extracted
with ethyl acetate (3ꢃ40 mL). The combined extracts were
dried (MgSO4) and evaporated to dryness. The crude mate-
rial was purified by flash chromatography on silica gel. The
spectroscopic data for all the synthesized compounds are
given in the Supporting Information.
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Acknowledgements
Financial support of this work by the University of Zꢀrich
and the Swiss National Science Foundation (SNSF) are ac-
knowledged.
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