Journal of Organic Chemistry p. 1948 - 1951 (1989)
Update date:2022-09-26
Topics:
Mirviss, Stanley B.
A short, high-yield method for the synthesis of ω-unsaturated acids have been developed that precludes any double-bond migration or hydrogenation.Key is the coupling reaction between Grignards of ω-unsaturated alkyl halides and the bromomagnesium salt of ω-bromo fatty acids.The reaction has been successfully extended to ω-bromo nitriles.The use of ω-chloro acids or α-bromo acids gives lower yields of heterocoupling products and substantial homocoupling.A catalyst study shows Li2CuCl4 to yield the most heterocoupling of several catalysts tried for the chloro acids, and Ni(II) or Cu(I) are best for the α-bromo acids.
View MoreAnhui Jiatiansen Agrochemical Co.,Ltd
Contact:15366811918
Address:chemical industrial park,xiangyu town,dongzhi county,anhui,china
SICHUAN ZHONGBANG NEW MATERIAL CO., LTD
website:http://www.zhongbangst.com
Contact:86-830-2585019
Address:sichuan,china
Chengdu Daoerji Medical Technology Co., Ltd
Contact:86-28-85528891
Address:Southwest University For Nationalities,Wuhou District,Chengdu City,Sichuan Province
Hangzhou jls Flame Retardants Chemical Co.,Ltd
Contact:+86-571-87250387/87250386
Address:MOGANSHAN RODA 1418# SHANGCHENG INDUSTRIAL PARK
Chiral Quest (Suzhou) Company Ltd
website:http://www.chiralquest.com
Contact:+86-0512-62956066
Address:B1/9, 218 Xinghu Street, Suzhou Industrial Park
Doi:10.1021/ol301155b
(2012)Doi:10.1002/adsc.201200364
(2012)Doi:10.1039/b925418h
(2010)Doi:10.1021/ja904368n
(2009)Doi:10.1021/ol902307m
(2009)Doi:10.1016/j.tetlet.2009.08.084
(2009)