Journal of Medicinal Chemistry p. 1618 - 1623 (1992)
Update date:2022-09-26
Topics:
Nihro, Yasunori
Sogawa, Satoshi
Izumi, Akihiro
Sasamori, Akihiro
Sudo, Tadamitsu
et al.
Structural modification of ascorbic acid by substitution of the 3-hydroxy group with lipophilic moieties has allowed the development of agents for treating reperfusion injury.These ascorbic acid derivatives inhibited lipid peroxidation, and some of them also reduced coronary reperfusion-induced arrhythmias in anesthetized rats.We found that 3-O-<(dodecylcarbonyl)methyl>ascorbic acid (8) was protective against reperfusion injury without directly influencing hemodynamics. 2-O-Octadecylascorbic acid (19) and 5,6-O-dodecylideneascorbic acid (15) also exhibited a marked effect on reperfusion injury, but significantly reduced the arterial blood pressure and heart rate in rats.
View MoreShanghai WinTide BioTechnology Co.,Ltd
Contact:86-21-37100630
Address:No. 908 Yunhe Road, Fengxian district, Shanghai
Zhangjiagang Golden Reach Fine Chemical Co.,LTD.
Contact:+86-512-6585 6968
Address:Changfu Road, Dongsha Chemical Industry Park, Zhangjiagang City, Jiangsu Province, China
HANGZHOU TOYOND BIOTECH CO., LTD
Contact:+86-571-86965177
Address:No. 189, Fengqi East Road, Hangzhou, China
Shijiazhuang Haitian Amino Acid Co., Ltd.
Contact:+86-311-88908111
Address:Shijiazhuang Hebei province,China
Shanghai Zhihua ChemTech Co., Ltd.
Contact:+86-13774313779
Address:Room 817 Suite B 3333 Shenjiang Road
Doi:10.1007/BF00960350
()Doi:10.1016/S0040-4020(01)85436-3
(1990)Doi:10.1142/S1088424610002938
(2010)Doi:10.1002/chem.201900951
(2019)Doi:10.1021/ol2005159
(2011)Doi:10.1248/cpb.44.515
(1996)