Heterocycles p. 2561 - 2573 (1999)
Update date:2022-07-29
Topics:
Goeker, Hakan
Ayhan-Kilcigil, Guelguen
Tuncbilek, Meral
Kus, Canan
Ertan, Rahmiye
Kendi, Engin
Oezbey, Sueheyla
Fort, Merce
Garcia, Celia
Farre, Antonio J.
A number of benzimidazoles, having several substituents on the azole and benzene nuclei and C-2 (methylamino, ethylenediamine, morpholine, piperazine and piperidine) were prepared. Regioselective synthesis was designed for the N1-alkyl substituted benzimidazoles (14-15). X-Ray structure analysis of (14) was also revealed. Compounds were evaluated for their in vitro H1- antihistaminic activity in the isolated guinea-pig ileum method. The compound (11) exhibits best activity.
View MoreHuangshi Meifeng Chemical Co.,ltd.
Contact:+86-714-6516706
Address:1941-4-3#,Hubin Avenue,Huangshi,Hubei,China
Contact:+91 - 22 - 26355700
Address:17, Lotus Business Park, Andheri West
Hangzhou jls Flame Retardants Chemical Co.,Ltd
Contact:+86-571-87250387/87250386
Address:MOGANSHAN RODA 1418# SHANGCHENG INDUSTRIAL PARK
website:http://www.hope-chem.com
Contact:86-21-58090396-805
Address:Floor 4, Building 5, No.588 Tianxiong Road, Zhoupu International Medical Zone, ShangHai, China
Jinan Yijialian Economic and Trade Development Co., Ltd.
Contact:+86 0531-66729596
Address:jinan
Doi:10.1246/bcsj.73.429
(2000)Doi:10.1016/S0020-1693(00)85398-0
(1989)Doi:10.1021/jm00063a018
(1993)Doi:10.1021/jo00284a037
(1989)Doi:10.1016/0022-328X(89)87357-7
(1989)Doi:10.1039/c003234d
(2010)