Journal of the American Chemical Society
COMMUNICATION
Scheme 1. Studies of Hydrogen Bondinga
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a Ar = 2,6-diisopropylphenyl; Ar0 = 4-methoxylphenyl.
of the transformation presented here, the catalysis approach of
the Buchwald fluorination, and the ability to fluorinate complex
molecules late-stage as accomplished by the silver-catalyzed
fluorination would significantly advance the field of fluorination.
’ ASSOCIATED CONTENT
S
Supporting Information. Experimental procedures, spec-
b
troscopic data for all new compounds, and crystallographic data
(CIF). This material is available free of charge via the Internet at
’ AUTHOR INFORMATION
Corresponding Author
’ ACKNOWLEDGMENT
We thank Dr. Shao-Liang Zheng for his help with X-ray data
collection and structure determination. This work was supported
by NSF (CHE-0952753) and NIH-NIGMS (GM088237).
’ REFERENCES
(1) For transition-metal-mediated CꢀF bond formation, see:
(a) Hull, K. L.; Anani, W. Q.; Sanford, M. S. J. Am. Chem. Soc. 2006,
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dx.doi.org/10.1021/ja2048072 |J. Am. Chem. Soc. 2011, 133, 11482–11484