Organic Letters
Letter
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(8) Since the indium salt showed catalytic activity for the cyanation of
ketimine, we envisioned that the indium catalyst could also be
acceptable for the typical Strecker reaction of a ketone. When
acetophenone (0.6 mmol) and aniline (0.9 mmol) were treated with
InBr3 (10 mol %) and Me3SiCN (1.5 equiv) in toluene, as expected, the
corresponding quaternary α-aminonitrile 10 was obtained in a 96%
yield.
D
Org. Lett. XXXX, XXX, XXX−XXX