Tetrahedron Letters p. 4311 - 4314 (1997)
Update date:2022-09-26
Topics:
Ojea, Vicente
Conde, Susana
Ruiz, Maria
Fernandez, Ma Carmen
Quintela, Jose Ma
Face-selective 1,6-addition of lithiated Schollkopf's bislactime ether 5 to 4-substituted, 1,4- or 3,4-disubstituted 1E,3E-butadienylphosphonates 6a-d allows a direct and stereocontrolled access to semi-rigid AP6 analogues, the 2,3-anti-4E 2-amino-6-phosphono-4-hexenoic acid derivatives 4a-c. The relative stereochemistry was assigned from a NMR study of the cyclic derivative 12c. Tenmembered trans-fused chair-boat-like transition states are invoked to rationalize the stereochemical outcome of the addition.
View MoreContact:+(852) 301-98033
Address:Flat C, 23/F, Lucky Plaza, 315-321 Lockhart Road, Wan Chai, Hong Kong
Yancheng Smiling Imp & Exp Co., Ltd.
Contact:+86-515-83173586
Address:Rm1207, BLD#03, Phoenix Plaza, Juheng Road, Yancheng, Jiangsu, P.R. China
website:http://www.lidepharma.com
Contact:+86-25-58409506
Address:11F, Building A1, No.288 North Zhongshan Road, Gulou District, Nanjing,210003, P.R.China.
Chengdu NoVi Biotechnology Co., Ltd.
Contact:13551243286/028-81458053
Address:NO.168-1-224 JULONG ROAD WUHOU DISTRICT, CHENGDU CITY,SICHUAN PROVINCE
Suzhou HeChuang Chemical Co.,Ltd.
Contact:+86-512-88800520
Address:No.9 Guanchao Rd,Changshu Advanced Materials Industy Park
Doi:10.1080/00397919708004187
(1997)Doi:10.1021/om9703245
(1997)Doi:10.1055/s-1997-5748
(1997)Doi:10.1016/S0960-894X(97)10151-2
(1998)Doi:10.1021/ic970189o
(1997)Doi:10.1039/a806959j
(1998)