Bioorganic and Medicinal Chemistry Letters p. 1607 - 1612 (1998)
Update date:2022-08-02
Topics:
Shin, Kye Jung
Yoo, Kyung Ho
Kim, Dong Jin
Park, Sang Woo
Ko, Bong Suck
Lee, Sang Joo
Huh, Jae Doo
Park, Seung Yong
The synthesis and biological activity of the novel series of 1β- methylcarbapenems, 1 and 2 were described. Most compounds displayed high potent antibacterial activity. The best compound in this series, 2a (IH201; R2=NH2) showed an excellent and a broad spectrum as well as high renal DHP- I stability. It also possessed good in vivo efficacy and high safety.
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