Chemical and Pharmaceutical Bulletin p. 131 - 139 (2000)
Update date:2022-08-04
Topics:
Inaba, Takihiro
Tanaka, Keiichi
Takeno, Ryuko
Nagaki, Hideyoshi
Yoshida, Chosaku
Takano, Shuntaro
A group of derivatives of 7-methanesulfonylamino-6-phenoxychromone (1) at the pyrone and phenoxy rings was synthesized starting with 4-chloro-3- nitroanisole and evaluated against acute and chronic inflammations in oral administration in animals. Significant potency in the rat models of carrageenin-induced edema (CPE) and adjuvant-induced arthritis (AA) was realized with 2'-fluoro and 2',4'-difluoro derivatives (9a and 9d), and 3- formylamino derivative (19a) and its 2'-fluoro and 2',4'-difluoro compounds (22a and 22d), displaying AA therapeutic effect of ED40=2.5-7.1 mg/kg/d for 7 d and AA prophylactic effect of 53-70% inhibition at the dosage of 3 mg/kg/d for 22 d. To identify a candidate for further pharmacological study, the five compounds were subjected to evaluation of their gastro-ulcerogenic liability, leading to selection of the fluorine-free compound 19a which did not cause acute ulceration at 300 mg/kg in oral administration in rats. Compound 19a (ED40=3.6 mg/kg in established AA) possessed good therapeutic efficacy against type II collagen-induced arthritis in DBA/1J mice with doses of 30 and 100 mg/kg, suggesting the development of 19a (designated T-614) as a prospective disease-modifying antirheumatic agent. In addition, a preparative-scale synthetic route to T-614 has been established.
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Doi:10.1007/BF00480723
()Doi:10.1016/S0040-4039(00)01328-9
(2000)Doi:10.1016/S0040-4020(01)91617-5
(1971)Doi:10.1021/jp308624h
(2012)Doi:10.1039/b004594m
(2000)Doi:10.1021/jm00288a027
(1971)