Journal of Medicinal Chemistry p. 1408 - 1412 (1982)
Update date:2022-08-05
Topics:
Erhardt, Paul W.
Woo, Chi M.
Anderson, William G.
Gorczynski, Richard J.
Several short-acting β-adrenergic receptor blocking agents have been prepared by incorporating ester functions into the aryl portion of certain (aryloxy)propanolamine systems.In particular, methyl 3-<4-<2-hydroxy-3-(isopropylamino)propoxy>phenyl>propionate hydrochloride (ASL-8052) was found to be a moderately potent, cardioselective compound with a short duration of action when determined in in vivo canine models.
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Doi:10.1021/ol048054r
(2005)Doi:10.1016/S0040-4039(00)87532-2
(1982)Doi:10.1248/cpb.28.2580
(1980)Doi:10.1016/S0040-4039(00)87459-6
(1982)Doi:10.1021/ja00390a008
(1982)Doi:10.1021/jo00148a034
(1982)