Journal of Pharmaceutical Sciences p. 733 - 736 (1979)
Update date:2022-08-11
Topics:
Roman
Yates
Millar
O'Neill
Zweig
A method was developed for the analysis of testosterone 17-enanthate 3-benzilic acid hydrazone, 17-β-estradiol 3,17-dienanthate, an estradiol benzoate combinations dissolved in an oily vehicle. Testosterone 17-enanthate 3-benzilic acid hydrazone was separated from the other drugs and vehicle components by chromatography on an acetonitrile-infusorial earth column followed by quantitation using UV spectroscopy. The estradiol esters were separated from the oil by an additional chromatographic step using a heptane-silanized infusorial earth column prior to quantitation by GLC. Subjecting formulations to elevated temperatures resulted in detectable losses for testosterone 17-enanthate 3-benzilic acid hydrazone and 17-β-estradiol 3,17-dienanthate. For both drugs, degradation was due to hydrolysis; the degradation products, testosterone 17-enanthate and 17-β-estradiol 17-enanthate, did not interfere with the intact drug determination. Methods also were developed to estimate degradation product levels in the formulation.
View MoreWudi Reaction Pharma&Chemical Co.,Ltd.
website:http://www.ruixinchem.com/
Contact:86-543-2257986
Address:Xinhai Industrial Zone, Wudi County,Shandong Province,China.
Hangzhou Yanshan Chemical Co.,Ltd.
Contact:86-571- 87698076
Address:Room 1001, #1 Building, Zhongtian MCC, No.2 Youzhinong, Wenyi West Road, Xihu District, Hangzhou, China
Shanghai Pinewood Fine Chemical Co., Ltd.
website:http://www.pinewoodchem.com
Contact:0086-21-62417129,62414096
Address:Suite B, 27F, No.2, Lane 600, Tianshan Road, Shanghai
website:http://www.guarson.com
Contact:+86-523-88059600,+86-13805268803
Address:Room B1006,Yafang Building,Jiangyan Avenue,Jiangyan District, Taizhou City,Jiangsu,China
Tianjin Pharmacn Medical Technology Co.,Ltd.
Contact:86-22-60122566ext.866(English),23359620
Address:Green Industrial Base, 6 Haitaifazhan Sixth Rd., Huayuan Industrial Area, Tianjin, 300384, China
Doi:10.1055/s-0029-1217973
(2009)Doi:10.1016/0304-5102(89)80176-2
(1989)Doi:10.1016/S0040-4039(99)00244-0
(1999)Doi:10.1007/BF00807158
(1995)Doi:10.1002/chem.200902790
(2010)Doi:10.1055/s-0029-1219941
(2010)