New Journal of Chemistry p. 1714 - 1722 (2017)
Update date:2022-08-17
Topics:
Saravanan, Velautham
Kannan, Ayyavoo
Rajakumar, Perumal
A new class of triazoloferrocenyl conjugates (1, 2 and 3) was obtained by copper(i) catalyzed click chemistry, specifically the alkyne azide cycloaddition (CuAAC) of bis(β-hydroxyl)arylalkyneether with suitable ferrocenyl azides. The synthesized bis(β-hydroxyl)arylether linked ferrocenyl conjugates 1, 2 and 3 exhibit antifungal activity against fungal pathogens, viz. Candida albicans, Candida glabrata and Candida crusi, comparable to that of amphotericin B and also show excellent anticancer activity against MCF-7 cell lines.
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