Beilstein J. Org. Chem. 2019, 15, 558–566.
11.Bhattacharjee, N.; Urrios, A.; Kang, S.; Folch, A. Lab Chip 2016, 16,
trolled syringe pumps and microreactors, the preparation of
glycosyl donors and glycosylation reactions were performed in
a cascade fashion to show the viability of this system.
12.Parra-Cabrera, C.; Achille, C.; Kuhn, S.; Ameloot, R. Chem. Soc. Rev.
13.McDonald, J. C.; Chabinyc, M. L.; Metallo, S. J.; Anderson, J. R.;
Stroock, A. D.; Whitesides, G. M. Anal. Chem. (Washington, DC, U. S.)
Supporting Information
14.Kitson, P. J.; Rosnes, M. H.; Sans, V.; Dragone, V.; Cronin, L.
15.Elias, Y.; Rudolf von Rohr, P.; Bonrath, W.; Medlock, J.; Buss, A.
Chem. Eng. Process. 2015, 95, 175–185.
Supporting Information File 1
All details for the 3D-printed lab equipment and reactors
(full part list, exploded-view CAD drawings, Arduino
wiring) and all experimental data of the chemical reactions
and NMR spectra.
16.Capel, A. J.; Wright, A.; Harding, M. J.; Weaver, G. W.; Li, Y.;
Harris, R. A.; Edmondson, S.; Goodridge, R. D.; Christie, S. D. R.
17.Comina, G.; Suska, A.; Filippini, D. Lab Chip 2014, 14, 2978–2982.
Supporting Information File 2
18.Waheed, S.; Cabot, J. M.; Macdonald, N. P.; Lewis, T.; Guijt, R. M.;
Paull, B.; Breadmore, M. C. Lab Chip 2016, 16, 1993–2013.
This zip-file includes all 3D-printed parts as stl-files for
direct 3D printing, as well as stp-files for editing the 3D
models, if necessary. It also contains the Arduino software
code as an ino-file for controlling of the syringe pumps.
19.Chen, C.; Mehl, B. T.; Munshi, A. S.; Townsend, A. D.; Spence, D. M.;
Martin, R. S. Anal. Methods 2016, 8, 6005–6012.
20.Dragone, V.; Sans, V.; Rosnes, M. H.; Kitson, P. J.; Cronin, L.
22.Rodbell, M. Angew. Chem., Int. Ed. Engl. 1995, 34, 1420–1428.
Acknowledgements
We thank our in-house metal and electronic workshop, espe-
cially Fero Digel for helping with the assembly of the pumps
and Tobias Wolf for helping with the Arduino programming.
23.Geyer, K.; Seeberger, P. H. Helv. Chim. Acta 2007, 90, 395–403.
24.Cancogni, D.; Lay, L. Synlett 2014, 25, 2873–2878.
25.Matthies, S.; McQuade, D. T.; Seeberger, P. H. Org. Lett. 2015, 17,
References
26.Ratner, D. M.; Murphy, E. R.; Jhunjhunwala, M.; Snyder, D. A.;
Jensen, K. F.; Seeberger, P. H. Chem. Commun. 2005, 578–580.
1. Plutschack, M. B.; Pieber, B.; Gilmore, K.; Seeberger, P. H.
Chem. Rev. 2017, 117, 11796–11893.
28.Macdonald, N. P.; Cabot, J. M.; Smejkal, P.; Guijt, R. M.; Paull, B.;
Breadmore, M. C. Anal. Chem. (Washington, DC, U. S.) 2017, 89,
2. Britton, J.; Raston, C. L. Chem. Soc. Rev. 2017, 46, 1250–1271.
3. Trobe, M.; Burke, M. D. Angew. Chem., Int. Ed. 2018, 57, 4192–4214.
29.Anciaux, S. K.; Geiger, M.; Bowser, M. T.
4. Sharma, M. K.; Acharya, R. B.; Shukla, C. A.; Kulkarni, A. A.
5. Adamo, A.; Beingessner, R. L.; Behnam, M.; Chen, J.; Jamison, T. F.;
Jensen, K. F.; Monbaliu, J.-C. M.; Myerson, A. S.; Revalor, E. M.;
Snead, D. R.; Stelzer, T.; Weeranoppanant, N.; Wong, S. Y.; Zhang, P.
6. Au, A. K.; Huynh, W.; Horowitz, L. F.; Folch, A. Angew. Chem., Int. Ed.
7. Rossi, S.; Puglisi, A.; Benaglia, M. ChemCatChem 2018, 10,
Anal. Chem. (Washington, DC, U. S.) 2016, 88, 7675–7682.
30.Rossi, S.; Porta, R.; Brenna, D.; Puglisi, A.; Benaglia, M.
Angew. Chem., Int. Ed. 2017, 56, 4290–4294.
31.Rao, Z. X.; Patel, B.; Monaco, A.; Cao, Z. J.; Barniol-Xicota, M.;
Pichon, E.; Ladlow, M.; Hilton, S. T. Eur. J. Org. Chem. 2017,
32.Chapman, M. R.; Kwan, M. H. T.; King, G.; Jolley, K. E.; Hussain, M.;
Hussain, S.; Salama, I. E.; González Niño, C.; Thompson, L. A.;
Bayana, M. E.; Clayton, A. D.; Nguyen, B. N.; Turner, N. J.; Kapur, N.;
Blacker, A. J. Org. Process Res. Dev. 2017, 21, 1294–1301.
8. Ko, D.-H.; Gyak, K.-W.; Kim, D.-P. J. Flow Chem. 2017, 7, 72–81.
9. Kitson, P. J.; Glatzel, S.; Chen, W.; Lin, C.-G.; Song, Y.-F.; Cronin, L.
10.Capel, A. J.; Edmondson, S.; Christie, S. D. R.; Goodridge, R. D.;
Bibb, R. J.; Thurstans, M. Lab Chip 2013, 13, 4583–4590.
33.Mo, Y.; Jensen, K. F. React. Chem. Eng. 2016, 1, 501–507.
34.Sprecher, H.; Payán, M. N. P.; Weber, M.; Yilmaz, G.; Wille, G.
565