Organic Process Research and Development p. 1178 - 1190 (2019)
Update date:2022-08-16
Topics:
Martinot, Theodore A.
Ardolino, Michael
Chen, Lu
Lam, Yu-Hong
Li, Chaomin
Maddess, Matthew L.
Muzzio, Daniel
Qi, Ji
Saurí, Josep
Song, Zhiguo J.
Tan, Lushi
Vickery, Thomas
Yin, Jingjun
Zhao, Ralph
The development of a stereospecific synthesis of a IDO1-selective inhibitor is described. The synthetic strategy toward enabling early discovery efforts along with additional findings pertaining to process safety that limited scalability are outlined. A convergent approach that supported the synthesis of material suitable for early preclinical and/or good laboratory practice toxicology studies and avoided the formation of key high-energy intermediates is summarized.
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Doi:10.1016/S0040-4039(00)75417-7
(1968)Doi:10.1021/ma4022554
(2013)Doi:10.1021/jo01093a028
(1959)Doi:10.1021/ja01117a063
(1953)Doi:10.1007/s10975-008-2003-4
(2008)Doi:10.1080/15533174.2012.749895
(2013)