Canadian Journal of Chemistry p. 1184 - 1188 (1986)
Update date:2022-08-25
Topics:
Oae, Shigeru
Kadoma, Yoshihito
The rates of aminolyses of p-toluenesulfonyl chloride with primary and tertiary amines have been determined both in acetonitrile and in ethanol.The Broensted plots of log krel again pKa' values fo amines (except hydrazine and 1,8-naphthyridine in acetonitrile) gave a good correlation when the aminolyses were carried out in acetonitrile.In ethanol, however, although Broensted plots with all tertiary amines show a good correlation, less basic hydrazine shows a higher reactivity than n-butylamine.The abnormal rate enhancement found with hydrazine is undoubtedly due to the α-effect, while with 1,8-naphthyridine in acetonitrile is considered to be due to the repulsion of two lone electron pairs on the two nitrogen atoms in 1,8-naphthyridine.
View Moreshanghai hekang chemical co.ltd
Contact:021-54173790
Address:328 WuHe Road, Building #A, 2nd Floor, Minhang, Shanghai 201109, China
Zhejiang Haizhou Pharmaceutical Co., Ltd.
website:https://www.haizhoupharma.com/
Contact:+86 576 88221016
Address:No. 19, Donghai 5th Avenue, Yanhai Industrial Zone, Linhai, Zhejiang, China
Airsea(Taizhou) Pharmaceutical Limited
Contact:+86-576-88057622
Address:Dubei, Duqiao, Linhai, Taizhou, Zhejiang, China Zip: 317016
Jiangxi Huashi Pharmaceutical Co., Ltd
Contact:+86-795-4509628
Address:Ningbo Ave., Fengtian Industrial Park, Fengxin Country, Jiangxi, China.
Contact:0086-573-82201031
Address:Jiaxing Industrial Park, Daqiao Town, Jiaxing
Doi:10.1002/ejic.201500629
(2015)Doi:10.1002/anie.201206428
(2012)Doi:10.1016/S0040-4039(03)01301-7
(2003)Doi:10.1080/00397911.2021.1880594
(2021)Doi:10.1002/hlca.19730560808
(1973)Doi:10.1016/S0022-1139(01)00472-9
(2001)