Chemistry - A European Journal
10.1002/chem.201704534
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radioiodinated MIBG, a tracer used for the imaging of cancer.
Current studies are investigating the extension of this
methodology for the preparation of existing and novel SPECT
imaging agents.
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3 2
microwave tube and heated under microwave irradiation at 90 °C for 5
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purified by column chromatography as needed.
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needed.
[
[
10] The shortest reaction times reported are 1 h, with other reactions
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General procedure C: Radioiodination
1
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solution of 4-methoxybenzeneboronic acid 1b (0.60 mg, 3.9 µmol) and
Ph PAuNTf (3.0 mg, 2.0 µmol) in dimethylcarbonate (0.1 mL) was added
3 2
and the reaction mixture heated to 90 °C for 20 minutes. The reaction
mixture was then removed by syringe and diluted with a 1:1 mixture of
acetonitrile and water (0.5 mL). Analysis of this solution by analytical
radio-HPLC showed a radiochemical yield of 100%.
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Acknowledgements
We thank Heriot-Watt University (James Watt Scholarship for
SW) and EPSRC (studentship for KMO, EP/K503058/1) for
funding. Mass spectrometry data was acquired at the EPSRC
UK National Mass Spectrometry Facility at Swansea University.
Keywords: gold catalysis • iodination • radiochemistry •
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radioiodination • radiopharmaceuticals
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