Journal of Molecular Liquids p. 428 - 441 (2018)
Update date:2022-08-10
Topics:
Rezki, Nadjet
Messali, Mouslim
Al-Sodies, Salsabeel A.
Naqvi, Arshi
Bardaweel, Sanaa K.
Al-blewi, Fawzia F.
Aouad, Mohamed R.
El Ashry, El Sayed H.
An array of dicationic pyridinium ionic liquids (DILs) based hydrazone linkage were designed and synthesized via the quaternization of the appropriate bispyridine hydrazone with different phenacyl halides and led to the formation of halogenated DILs, which undergo metathesis reaction to give the specific task dicationic pyridinium liquids carrying fluorinated counter anions (PF6 ?, BF4 ?, CF3COO?). The newly synthesized DILs were well characterized using whole spectroscopic data. The Anticancer evaluation of DILs against breast and colon cancer cell lines revealed that compound 22 appears to be the most active compound in the series with IC50 in the two-digit micromolar range. The in-vitro anticancer results were further supported by in-silico molecular docking studies revealing the highest potency of compound 22. The docking analysis demonstrated good docking score and binding affinities of the synthesized compounds on the target protein PI3Kinase.
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