MedChemComm p. 1498 - 1504 (2017)
Update date:2022-08-17
Topics:
Li, Bo
Yang, Yongan
Chen, Liuzeng
Chen, Shichao
Zhang, Jing
Tang, Wenjian
Based on the SAR analysis of glycyrrhizin, 18α-glycyrrhetinic acid monoglucuronide (18α-GAMG) with strong inhibition against LPS-induced NO and IL-6 production in RAW264.7 cells was discovered. Western blotting and immunofluorescence results showed that 18α-GAMG reduced the expression of iNOS, COX-2, and MAPKs, as well as activation of NF-κB in the LPS-stimulated RAW264.7 cells. Further in vivo results showed that 18α-GAMG could significantly improve the pathological changes of CCl4-induced hepatic fibrosis.
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