1-Phenyl-3,4-dimethylphosphole

Base Information

• Chemical Name: 1-Phenyl-3,4-dimethylphosphole
• CAS No.: 30540-36-4
• Molecular Formula: C12H13P
• Molecular Weight: 188.209
• Mol file: 30540-36-4.mol

Synonyms:1H-Phosphole,3,4-dimethyl-1-phenyl;1-phenyl-3,4-dimethyl-phosphole;1-phenyl-2,4-dimethylphosphole;3,4-dimethyl-1-phenyl phosphole;1-phenyl-3,4-dimethylphopshole;

Chemical Property of 1-Phenyl-3,4-dimethylphosphole

Chemical Property:

• PSA: 13.59000
• LogP: 4.08680

Purity/Quality:

98% ^*data from raw suppliers

3,4-Dimethyl-1-phenyl-1H-phosphole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Phenyl-3,4-dimethylphosphole

There total 11 articles about 1-Phenyl-3,4-dimethylphosphole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-Bromo-3,4-dimethyl-1-phenyl-2,5-dihydrophospholium bromide → 3,4-dimethyl-1-phenylphosphole (30540-36-4)

Guidance literature:

With α-picoline; In hexane; dichloromethane; Ambient temperature;

DOI:10.1055/s-1981-29670

Reference yield: 50.0%

Dichlorophenylphosphine (644-97-3) + 2,3-dimethyl-buta-1,3-diene (513-81-5) → 3,4-dimethyl-1-phenylphosphole (30540-36-4)

Guidance literature:

Dichlorophenylphosphine; 2,3-dimethyl-buta-1,3-diene; at 20 ℃; for 168h; Inert atmosphere;

With α-picoline; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.1021/acs.orglett.0c00359

Reference yield:

α-picoline (109-06-8) + 4-methyl-1,3-pentadiene (926-56-7,54363-49-4) + Dichlorophenylphosphine (644-97-3) + phenyldibromophosphine (1073-47-8) → 3,4-dimethyl-1-phenylphosphole (30540-36-4)

Guidance literature:

With hydrogenchloride; In hexane; dichloromethane; nitrogen; water;

upstream raw materials:

2,3-dimethyl-buta-1,3-diene

phenyldibromophosphine

Dichlorophenylphosphine

α-picoline

Downstream raw materials:

4,5-dimethyl-1-oxo-1-phenyl-2-thiophen-3-yl-1,2-dihydro-1λ⁵-phosphinin-2-ol

2-(4-chloro-phenyl)-4,5-dimethyl-1-oxo-1-phenyl-1,2-dihydro-1λ⁵-phosphinin-2-ol

2-(4-methoxy-phenyl)-4,5-dimethyl-1-oxo-1-phenyl-1,2-dihydro-1λ⁵-phosphinin-2-ol

1-n-butyl-3,4-dimethylphosphole

Refernces

• 1、 ?ejka, Jan,Polák, Peter,Tobrman, Tomá?. "Formal Transition-Metal-Catalyzed Phosphole C-H Activation for the Synthesis of Pentasubstituted Phospholes". . . Retrieved 2020.
• 2、 -. "3,4-dimethyl-2,5,6-tris(p-sulfonatophenyl)-1-phosphanorbornadiene, process for the preparation thereof and process for the hydroformylation of olefinnically unsaturated compounds". . . Retrieved 2008/06/13.