(S)-2-(benzyloxy)propan-1-ol

Base Information

• Chemical Name: (S)-2-(benzyloxy)propan-1-ol
• CAS No.: 33106-64-8
• Molecular Formula: C10H14O2
• Molecular Weight: 166.22
• Hs Code.: 2909499000
• DSSTox Substance ID: DTXSID60455719
• Nikkaji Number: J71.953F
• Wikidata: Q72442537
• Mol file: 33106-64-8.mol

Synonyms:(S)-2-(benzyloxy)propan-1-ol;33106-64-8;(2S)-2-phenylmethoxypropan-1-ol;SCHEMBL647500;(S)-2-Benzyloxypropane-1-ol;(2S)-2-benzyloxypropan-1-ol;DTXSID60455719;BWCRDMRLKBPUTD-VIFPVBQESA-N;MFCD09753514;AKOS006326706;(2S)-2-(BENZYLOXY)PROPAN-1-OL;BS-49997;F31051;EN300-6754275;A875424;J-019029

Chemical Property of (S)-2-(benzyloxy)propan-1-ol

Chemical Property:

• Vapor Pressure: 0.00505mmHg at 25°C
• Boiling Point: 263.8±15.0 °C(Predicted)
• PKA: 14.45±0.10(Predicted)
• PSA: 29.46000
• Density: 1.042±0.06 g/cm3(Predicted)
• LogP: 1.58400
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slig
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 166.099379685
• Heavy Atom Count: 12
• Complexity: 108

Purity/Quality:

98% purity ^*data from raw suppliers

(S)-2-(Benzyloxy)propan-1-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CO)OCC1=CC=CC=C1
• Isomeric SMILES: C[C@@H](CO)OCC1=CC=CC=C1
• Uses: An optically active alcohol

Technology Process of (S)-2-(benzyloxy)propan-1-ol

There total 70 articles about (S)-2-(benzyloxy)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl (S)-2-(benzyloxy)propionate (54783-72-1) → (S)-2-(benzyloxy)propan-1-ol (33106-64-8)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 - 20 ℃; for 2h;

DOI:10.1016/j.tet.2013.09.017

Reference yield: 100.0%

2-benzyloxypropionic acid methyl ester (53346-03-5) → 2-benzyloxypropanol (33106-26-2,33106-64-8,70448-03-2,87037-69-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 14h; Ambient temperature;

DOI:10.1021/jm950717a

Reference yield: 98.6%

1-<(tetrahydropyran-2-yl)oxyl>-2-benzyloxypropane (70448-02-1) → 2-benzyloxypropanol (33106-26-2,33106-64-8,70448-03-2,87037-69-2)

Guidance literature:

With Dowex 50W-X₈ resin; In methanol; for 1h; Ambient temperature;

DOI:10.1016/0008-6215(83)84007-5

upstream raw materials:

ethyl (S)-2-(benzyloxy)propionate

methyl (S)-2-(benzyloxy)propanoate

2-(benzyloxy)propanoic acid

(S)-2-(benzyloxy)propanal

Downstream raw materials:

1-O-(4-O-acetyl-2,3,6-tri-O-benzyl-α-D-glucopyranosyl)-3-deoxy-2(S)-glycerol

(2-benzyloxypropyl) bromoacetate

2-(benzyloxy)propanal

(R)-2-(benzyloxy)propan-1-ol

Refernces

• 1、 Moore, Lucas C.,Lo, Anna,Fell, Jason S.,Duong, Matthew R.,Moreno, Jose A.,Rich, Barry E.,Bravo, Martin,Fettinger, James C.,Souza, Lucas W.,Olmstead, Marilyn M.,Houk, Kendall N.,Shaw, Jared T.. "Acyclic Stereocontrol in the Additions of Nucleophilic Alkenes to α-Chiral N-Sulfonyl Imines". . p. 12214 - 12220. Retrieved 2019.
• 2、 -. "6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS". Paragraph 0954; 0956. . Retrieved 2021/11/13.
• 3、 Nakamura, Sho,Sayama, Misa,Uwamizu, Akiharu,Jung, Sejin,Ikubo, Masaya,Otani, Yuko,Kano, Kuniyuki,Omi, Jumpei,Inoue, Asuka,Aoki, Junken,Ohwada, Tomohiko. "Non-naturally Occurring Regio Isomer of Lysophosphatidylserine Exhibits Potent Agonistic Activity toward G Protein-Coupled Receptors". . p. 9990 - 10029. Retrieved 2020/10/18.