Ethyl 2-bromo-3-oxo-3-phenylpropanoate

Base Information

• Chemical Name: Ethyl 2-bromo-3-oxo-3-phenylpropanoate
• CAS No.: 55919-47-6
• Molecular Formula: C11H11BrO3
• Molecular Weight: 271.111
• Hs Code.: 2918300090
• Mol file: 55919-47-6.mol

Synonyms:Aceticacid, benzoylbromo-, ethyl ester (6CI);Ethyl 2-benzoyl-2-bromoacetate;Ethyl2-bromo-3-oxo-3-phenylpropanoate;Ethyl a-bromobenzoylacetate;NSC 41689;

Chemical Property of Ethyl 2-bromo-3-oxo-3-phenylpropanoate

Chemical Property:

• Vapor Pressure: 0.00112mmHg at 25°C
• Refractive Index: 1.548
• Boiling Point: 300.4 °C at 760 mmHg
• PKA: 7.09±0.26(Predicted)
• Flash Point: 135.5 °C
• PSA: 43.37000
• Density: 1.445 g/cm³
• LogP: 2.19590

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl2-Bromo-3-oxo-3-phenylpropanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 2-bromo-3-oxo-3-phenylpropanoate

There total 12 articles about Ethyl 2-bromo-3-oxo-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl 3-oxo-3-phenylpropionate (94-02-0) → ethyl 2-bromo-3-oxo-3-phenylpropionate (55919-47-6)

Guidance literature:

With hydrogenchloride; dihydrogen peroxide; potassium bromide; In toluene; at 20 ℃; for 1.5h;

DOI:10.1055/s-2006-948207

Reference yield: 94.0%

N-Bromosuccinimide (128-08-5) + ethyl 3-oxo-3-phenylpropionate (94-02-0) → ethyl 2-bromo-3-oxo-3-phenylpropionate (55919-47-6)

Guidance literature:

amberlyst-15; In ethyl acetate; at 20 ℃; for 0.25h;

DOI:10.1016/j.tetlet.2004.11.140

Reference yield: 89.0%

Ethyl 3-hydroxy-3-phenylpropanoate (5764-85-2) → ethyl 2-bromo-3-oxo-3-phenylpropionate (55919-47-6)

Guidance literature:

With N-Bromosuccinimide; dioxomolybdenum(VI) dichloride; In dichloromethane; at 30 ℃; for 5h;

DOI:10.1055/s-0028-1083273

upstream raw materials:

ethyl 3-oxo-3-phenylpropionate

N-Bromosuccinimide

Ethyl 3-hydroxy-3-phenylpropanoate

acetophenone

Downstream raw materials:

ethyl 7-methyl-2-phenylimidazo<1,2-a>pyrimidine-3-carboxylate

ethyl 7-ethoxy-2-phenylimidazo<2,1-b>benzothiazole-3-carboxylate

ethyl 2-benzoylimino-2,3-dihydro-6-ethoxybenzothiazole-3-acetate

2-(3-Hydroxy-propylamino)-4-phenyl-thiazole-5-carboxylic acid ethyl ester

Refernces

• 1、 Platte, Simon,Korff, Marvin,Imberg, Lukas,Balicioglu, Ilker,Erbacher, Catharina,Will, Jonas M.,Daniliuc, Constantin G.,Karst, Uwe,Kalinin, Dmitrii V.. "Microscale Parallel Synthesis of Acylated Aminotriazoles Enabling the Development of Factor XIIa and Thrombin Inhibitors". supporting information. p. 3672 - 3690. Retrieved 2021/08/07.
• 2、 Zhang, Jungan,Li, Peipei,Zeng, Hongyun,Huang, Yu,Hong, Wei. "Highly efficient and green synthesis of 2,4-diphenyl substituted thiazoles". supporting information. p. 735 - 741. Retrieved 2020/02/11.