3-Methylbenzyl fluoride

Base Information

• Chemical Name: 3-Methylbenzyl fluoride
• CAS No.: 456-44-0
• Molecular Formula: C8H9F
• Molecular Weight: 124.158
• Hs Code.: 2903999090
• Mol file: 456-44-0.mol

Synonyms:m-Methyl-benzylfluorid;3-methyl-benzyl fluoride;m-Xylyl chloride;3-(Chloromethyl)toluene;3-Methyl-benzylfluorid;1-(chloromethyl)-3-methyl-benzene;m-Methylbenzyl chloride;m-(Chloromethyl)toluene;3-Methylbenzyl chloride;

Chemical Property of 3-Methylbenzyl fluoride

Chemical Property:

• PSA: 0.00000
• LogP: 2.46450

Purity/Quality:

98%min ^*data from raw suppliers

3-Methylbenzylfluoride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Methylbenzyl fluoride

There total 8 articles about 3-Methylbenzyl fluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3-methylbenzyl fluorosulfonyldifluoroacetate → 1-methyl-3-(2,2,2-trifluoroethyl)benzene (50562-00-0) + 1-(fluoromethyl)-3-methylbenzene (456-44-0)

Guidance literature:

With copper(l) iodide; In N,N-dimethyl-formamide; at 60 ℃; for 6h;

DOI:10.1039/P19940000725

Reference yield: 24.0%

m-xylene (108-38-3,104809-90-7) → 2-fluoro-m-xylene (443-88-9) + 2,4-dimethylfluorobenzene (452-65-3) + 1-(fluoromethyl)-3-methylbenzene (456-44-0)

Guidance literature:

With caesium fluoroxysulphate; at 35 - 40 ℃; for 1h; Yields of byproduct given; inert atmosphere;

DOI:10.1021/jo00026a032

Reference yield: 3.0%

3-methylbenzyl chlorodifluoroacetate → 1-methyl-3-(2,2,2-trifluoroethyl)benzene (50562-00-0) + 1-(fluoromethyl)-3-methylbenzene (456-44-0)

Guidance literature:

With potassium fluoride; copper(l) iodide; In N,N-dimethyl-formamide; at 100 ℃; for 10h;

DOI:10.1039/P19940000725

upstream raw materials:

1-bromomethyl-3-methyl-benzene

m-xylene

pyridine

chloroform

Downstream raw materials:

α-ethoxy-m-xylene

Refernces

• 1、 Duan, Jian-Xing,Chen, Quing-Yun. "Novel Synthesis of 2,2,2-Trifluoroethyl Compounds from Homoallylic Alcohols: A Copper(I) Iodide-initiated Trifluoromethyl-Dehydroxylation Process". . p. 725 - 730. Retrieved 2007/10/02.