Cyclazosin hydrochloride

Base Information Edit

Chemical Name:Cyclazosin hydrochloride
CAS No.:146929-33-1
Molecular Formula:C₂₃H₂₇N₅O₄*ClH
Molecular Weight:473.959
Hs Code.:2934999090
UNII:RLN802138L
DSSTox Substance ID:DTXSID1040453
Wikidata:Q27132919
Mol file:146929-33-1.mol

Synonyms:Cyclazosin hydrochloride;146929-33-1;Cyclazosin HCl;(+)-Cyclazosin hydrochloride;UNII-RLN802138L;RLN802138L;((4aR,8aS)-4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)octahydro-1(2H)-quinoxalinyl)(2-furyl)methanone hydrochloride (1:1);((4aR,8aS)-4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl)-(furan-2-yl)methanone hydrochloride;((4aR,8aS)-4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)octahydroquinoxalin-1(2H)-yl)(2-furyl)methanone hydrochloride;(4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin-L-yl)furan-2-ylmethanone hydrochloride;[(4aR,8aS)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-(furan-2-yl)methanone;hydrochloride;Methanone, ((4aR,8aS)-4-(4-amino-6,7-dimethoxy-2-quinazolinyl)octahydro-1(2H)-quinoxalinyl)-2-furanyl-, hydrochloride (1:1), rel-;Quinoxaline, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)decahydro-, monohydrochloride, (4aR,8aS)-rel-;Quinoxaline, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)decahydro-, monohydrochloride, cis-;Methanone, [(4aR,8aS)-4-(4-amino-6,7-dimethoxy-2-quinazolinyl)octahydro-1(2H)-quinoxalinyl]-2-furanyl-, hydrochloride (1:1), rel-;Cyclazosin (hydrochloride);[(4aR,8aS)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)octahydroquinoxalin-1(2H)-yl](2-furyl)methanone hydrochloride;[(4aR,8aS)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)octahydroquinoxalin-1(2H)-yl](furan-2-yl)methanone hydrochloride;DTXSID1040453;CHEBI:63935;Q27132919;184033-31-6

Suppliers and Price of Cyclazosin hydrochloride

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Cyclazosin hydrochloride
5mg
$ 185.00

Sigma-Aldrich
Cyclazosin hydrochloride solid
5mg
$ 220.00

Sigma-Aldrich
Cyclazosin hydrochloride solid
25mg
$ 829.00

American Custom Chemicals Corporation
CYCLAZOSIN HYDROCHLORIDE 95.00%
25MG
$ 1298.86

American Custom Chemicals Corporation
CYCLAZOSIN HYDROCHLORIDE 95.00%
5MG
$ 769.29

Total 33 raw suppliers

Chemical Property of Cyclazosin hydrochloride Edit

Chemical Property:

Vapor Pressure:2.43E-19mmHg at 25°C
Boiling Point:691.1oC at 760 mmHg
Flash Point:371.7oC
PSA：106.95000
LogP:4.48190
Solubility.:H2O: 1.8 mg/mL
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:473.1829821
Heavy Atom Count:33
Complexity:668

Purity/Quality:: Cyclazosin hydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(C4C3CCCC4)C(=O)C5=CC=CO5)N)OC.Cl
Isomeric SMILES:COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN([C@@H]4[C@H]3CCCC4)C(=O)C5=CC=CO5)N)OC.Cl
Uses Cyclazosin hydrochloride is prazosin-related α1-adrenoceptor antagonist at α1-, α2-adrenoceptors, dopamine D2 and 5-HT1A receptors.

Technology Process of Cyclazosin hydrochloride

There total 5 articles about Cyclazosin hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: (+/-)-furan-2-yl(cis-octahydroquinoxalin-1yl)methanone

: 23680-84-4
2-chloro-6,7-dimethoxyquinazolin-4-amine

: 146929-33-1
cyclazosin

Guidance literature:: In i-Amyl alcohol; for 72h; Heating;
DOI:10.1021/jm00058a005

Reference yield:

: (+)-1-(2-furoyl)-cis-octahydroquinoxaline

: 23680-84-4
2-chloro-6,7-dimethoxyquinazolin-4-amine

: 146929-33-1
2-[(4aR,8aS)-4-(2-furoyl)octahydroquinoxalin-1(2H)-yl]-6,7-dimethoxyquinazolin-4-amine hydrochloride

Guidance literature:: (+)-1-(2-furoyl)-cis-octahydroquinoxaline; 2-chloro-6,7-dimethoxyquinazolin-4-amine; With N-ethyl-N,N-diisopropylamine; In i-Amyl alcohol; at 0 ℃; Heating / reflux;

With sodium hydroxide; In water;

With hydrogenchloride;