IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE

Base Information

• Chemical Name: IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE
• CAS No.: 78162-58-0
• Molecular Formula: C5H9 N3 O2 S
• Molecular Weight: 175.211
• Hs Code.: 2935009090
• Mol file: 78162-58-0.mol

Synonyms:1-(Dimethylaminosulfonyl)imidazole;1-(Dimethylsulfamoyl)imidazole; 1-(N,N-Dimethylsulfamoyl)imidazole;Imidazole-1-sulfonic acid dimethylamide;N,N-Dimethyl-1H-imidazole-1-sulfonamide; NSC 700551

Chemical Property of IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE

Chemical Property:

• Vapor Pressure: 0.000737mmHg at 25°C
• Melting Point: 48-51 °C(lit.)
• Boiling Point: 307.2°C at 760 mmHg
• PKA: 2.41±0.10(Predicted)
• Flash Point: 110 ºC
• PSA: 63.58000
• Density: 1.35g/cm³
• LogP: 0.61840
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(N,N-Dimethylsulfamoyl)-1H-imidazole ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE is an Imidazole (I350200) derivative, used in the preparation of Histamine H3 Receptor Agonists and druglike angiotensin II compounds with affinity for the AT2 r eceptor. 1-(N,N-Dimethylsulfamoyl)-1H-imidazole is an Imidazole (I350200) derivative, used in the preparation of Histamine H3 Receptor Agonists and druglike angiotensin II compounds with affinity for the AT2 receptor. 1-(Dimethylsulfamoyl)imidazole may be used to synthesize 1-(dimethylsulfamoyl)-2-imidazolecarboxaldehyde.

Technology Process of IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE

There total 5 articles about IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1H-imidazole (288-32-4) + dimethylamino sulfonyl chloride (13360-57-1) → N,N-dimethyl-1H-imidazole-1-sulfonamide (78162-58-0)

Guidance literature:

With triethylamine; In toluene; at 20 ℃; for 8h;

Reference yield: 93.0%

1H-imidazole (288-32-4) → N,N-dimethyl-1H-imidazole-1-sulfonamide (78162-58-0)

Guidance literature:

Reference yield:

dimethyl amine (124-40-3) + 3-(imidazole-1-sulfonyl)-1-methyl-3H-imidazol-1-ium triflate (489471-57-0) → N,N-dimethyl-1H-imidazole-1-sulfonamide (78162-58-0)

Guidance literature:

In acetonitrile; at 20 ℃;

DOI:10.1016/j.bmcl.2012.04.127

upstream raw materials:

1H-imidazole

dimethylamino sulfonyl chloride

2-tert-butyldimethylsilyl-N,N-dimethylimidazole-1-sulfonamide

dimethyl amine

Downstream raw materials:

2-hydroxy(diphenyl)methyl-N,N-dimethylimidazole-1-sulphonamide

1-N,N-dimethylsulfamoyl-2-tert-butyldimethylsilyl-5-(5-O-trityl-2-deoxy-D-erythro-pent-1-enofuranosyl)-1H-imidazole

2-tert-butyldimethylsilyl-N,N-dimethylimidazole-1-sulfonamide

3-(1-(dimethylsulfamoyl)-1H-imidazol-2-yl)-5-(5-((R)-2-teit-butoxycarbonylamino-1-phenylpropan-2-yl)-1,3,4-oxadiazol-2-yl)-N-methyl-N-(methylsulfonyl)benzenamine

Refernces

• 1、 -. "FERROPORTIN INHIBITORS AND METHODS OF USE". Paragraph 0339; 0340. . Retrieved 2020/07/07.
• 2、 -. "Method for synthesizing dexmedetomidine hydrochloride". Paragraph 0028; 0029; 0030. . Retrieved 2019/04/26.