2-BENZYLSULFANYL-1H-BENZOIMIDAZOLE

Base Information

• Chemical Name: 2-BENZYLSULFANYL-1H-BENZOIMIDAZOLE
• CAS No.: 51290-77-8
• Molecular Formula: C14H12N2S
• Molecular Weight: 240.329
• Mol file: 51290-77-8.mol

Synonyms:2-benzyl sulfanyl-1H-benzoimidazole;2-benzylthio benzimidazole;2-benzylmercaptobenzimidazole;

Chemical Property of 2-BENZYLSULFANYL-1H-BENZOIMIDAZOLE

Chemical Property:

• PSA: 53.98000
• LogP: 3.85520

Purity/Quality:

99% ^*data from raw suppliers

2-(Benzylthio)-1H-benzo[d]imidazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BENZYLSULFANYL-1H-BENZOIMIDAZOLE

There total 36 articles about 2-BENZYLSULFANYL-1H-BENZOIMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl bromide (100-39-0) + Benzimidazol-2-thiol (134469-07-1) → 2-(benzylthio)-1H-benzo[d]imidazole (51290-77-8)

Guidance literature:

With potassium carbonate; In acetone; at 60 ℃; for 8h;

DOI:10.1021/acs.orglett.9b02067

Reference yield: 98.0%

benzyl chloride (100-44-7) + Benzimidazol-2-thiol (134469-07-1) → 2-(benzylthio)-1H-benzo[d]imidazole (51290-77-8)

Guidance literature:

With reconstructed hydrotalcite; In ethanol; at 70 ℃; for 0.333333h; Reagent/catalyst; Time; Microwave irradiation; Cooling;

DOI:10.1055/s-0033-1339763

Reference yield: 96.0%

Benzimidazol-2-thiol (134469-07-1) + benzyl alcohol (100-51-6,185532-71-2) → 2-(benzylthio)-1H-benzo[d]imidazole (51290-77-8)

Guidance literature:

With 2,2,4,4,6,6-hexachloro-1,3,5-triaza-2,4,6-triphosphorine; at 50 ℃; for 0.0666667h; Neat (no solvent);

DOI:10.1055/s-0030-1261206

upstream raw materials:

2,3-dihydrobenzimidazol-2-thione

benzyl chloride

benzyl bromide

dibenzyl disulphide

Downstream raw materials:

1-benzyl-2-(benzylthio)-1H-benzo-[d]-imidazole

2-(benzylsulfonyl)-1-methyl-1H-benzo[d]imidazole

2-(benzyloxy)-1-methyl-1H-benzo[d]imidazole

Refernces

• 1、 Zhang,Hou,Hou,Liu. "Benzimidazole derivatives as novel inhibitors for the corrosion of mild steel in acidic solution: Experimental and theoretical studies". . p. 413 - 427. Retrieved 2019.
• 2、 Amer, Mohamed R.,Eissa, Ibrahim H.,El Ashry, El Sayed H.,Elkaeed, Eslam B.,Elshobaky, Ahmed,Hafez, Elsayed E.,Khalid, Asaad,Metwaly, Ahmed M.,Mohammed, Salih Osman. "Expression, Purification, and Comparative Inhibition of Helicobacter pylori Urease by Regio‐Selectively Alkylated Benzimidazole 2‐Thione Derivatives". . . Retrieved 2022/01/31.
• 3、 Lopes, Alexandra Basilio,Choury, Mickael,Wagner, Patrick,Gulea, Mihaela. "Tandem Double-Cross-Coupling/Hydrothiolation Reaction of 2-Sulfenyl Benzimidazoles with Boronic Acids". supporting information. p. 5943 - 5947. Retrieved 2019/08/26.