Morpholine-4-carboximidamide hydrochloride

Base Information

• Chemical Name: Morpholine-4-carboximidamide hydrochloride
• CAS No.: 5638-78-8
• Molecular Formula: C5H11N3O.ClH
• Molecular Weight: 165.623
• Hs Code.: 2934999090
• Mol file: 5638-78-8.mol

Synonyms:5638-78-8;Morpholine-4-carboximidamide hydrochloride;Morpholine-4-carboximidamide HCl;morpholine-4-carboximidamide;hydrochloride;MFCD20037392;4-Morpholinecarboximidamide monohydrochloride;Morpholine-4-carboximidamide Monohydrochloride;morpholine-4-carboxamidine hcl;Morpholincarboxamidinhydrochlorid;SCHEMBL1015413;DUXSXDMXKUUYHP-UHFFFAOYSA-N;AKOS016009582;4-morpholinecarboximidamide hydrochloride;Morpholine-4-carboximidamidehydrochloride;871246-20-7;AS-40594;SY225573;CS-0155197;FT-0686179;A924026

Chemical Property of Morpholine-4-carboximidamide hydrochloride

Chemical Property:

• Melting Point: 138-139℃
• PSA: 62.34000
• LogP: -0.05000
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 165.0668897
• Heavy Atom Count: 10
• Complexity: 109

Purity/Quality:

98%,99%, ^*data from raw suppliers

Morpholine-4-carboximidamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C(=N)N.Cl

Technology Process of Morpholine-4-carboximidamide hydrochloride

There total 5 articles about Morpholine-4-carboximidamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

morpholine (110-91-8,99108-56-2) + S-methylisothiourea hemisulphate (147895-43-0) → morpholinoformamidine hydrochloride (5638-78-8)

Guidance literature:

morpholine; S-methylisothiourea hemisulphate; In water; for 0.0833333h; Reflux;

With barium(II) chloride; In water; for 0.5h; Heating;

DOI:10.1016/j.ejmech.2015.06.024

Reference yield: 75.0%

morpholine (110-91-8,99108-56-2) + 1H-pyrazole-1-carboximidamide hydrochloride (4023-02-3) → morpholinoformamidine hydrochloride (5638-78-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 12h;

DOI:10.1055/s-0040-1707080

Reference yield: 66.0%

4,6-dimethoxy-2-(morpholin-4-yl)pyrimidine (1568908-87-1) → morpholinoformamidine hydrochloride (5638-78-8)

Guidance literature:

With hydrogenchloride; In water; at 80 ℃; for 12h; Sealed tube; Green chemistry;

DOI:10.1016/j.tetlet.2015.07.007

upstream raw materials:

morpholine

2-methylisothiourea sulphate

S-methylisothiourea hemisulphate

4,6-dimethoxy-2-(morpholin-4-yl)pyrimidine

Downstream raw materials:

6-amino-2-(morpholin-4'-yl)pyrimidin-4(3H)-one

2-morpholino-pyrimidine-4,6-diyldiamine

5-(o-methoxyphenoxy)-4,6-dihydroxy-2-(N-morpholino)-pyrimidine

7-benzyl-2-morpholin-4-yl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-one

Refernces

• 1、 Solomin, Vitalii V.,Seins, Alberts,Jirgensons, Aigars. "2-Aminoquinazolines by Chan-Evans-Lam Coupling of Guanidines with (2-Formylphenyl)boronic Acids". supporting information. p. 1507 - 1510. Retrieved 2020/07/24.
• 2、 Kaur, Hardeep,Balzarini, Jan,De Kock, Carmen,Smith, Peter J.,Chibale, Kelly,Singh, Kamaljit. "Synthesis, antiplasmodial activity and mechanistic studies of pyrimidine-5-carbonitrile and quinoline hybrids". supporting information. p. 52 - 62. Retrieved 2015/06/30.