5-Nitropyridine-2-carboxamide

Base Information

• Chemical Name: 5-Nitropyridine-2-carboxamide
• CAS No.: 59290-34-5
• Molecular Formula: C6H5N3O3
• Molecular Weight: 167.1222
• Hs Code.: 2933399090
• Mol file: 59290-34-5.mol

Synonyms:5-nitropyridine-2-carboxamide

Chemical Property of 5-Nitropyridine-2-carboxamide

Chemical Property:

• Melting Point: 246-247 °C
• Boiling Point: 397.8 °C at 760 mmHg
• Flash Point: 194.4 °C
• PSA: 101.80000
• Density: 1.476 g/cm³
• LogP: 1.31220
• Storage Temp.: Room temperature.

Purity/Quality:

99% ^*data from raw suppliers

5-nitropicolinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Nitropyridine-2-carboxamide

There total 4 articles about 5-Nitropyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-nitropicolinic acid (30651-24-2) → 5-nitropyridine-2-carboxamide (59290-34-5)

Guidance literature:

With pyridine; ammonium chloride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In ethyl acetate;

Reference yield:

2-bromo-5-nitropyridine (4487-59-6) → 5-nitropyridine-2-carboxamide (59290-34-5)

Guidance literature:

With biphenyl; Behandeln des Reaktionsprodukts in Aceton mit wss. HCl;

Reference yield:

5-nitro-pyridin-2-ylamine (4214-76-0,67476-67-9) → 5-nitropyridine-2-carboxamide (59290-34-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; aqueous hydrobromic acid / anschliessend Behandeln mit Brom und Behandeln des Reaktionsgemisches mit Natriumnitrit in Wasser

2: biphenyl / Behandeln des Reaktionsprodukts in Aceton mit wss. HCl

With biphenyl; sulfuric acid; hydrogen bromide;

upstream raw materials:

2-bromo-5-nitropyridine

5-nitro-pyridin-2-ylamine

5-nitropicolinic acid

Downstream raw materials:

5-hydroxypicolinic acid

5-amino-pyridine-2-carboxylic acid

5-Acetylaminopyridin-2-carbonsaeure

5-aminopyridine-2-carboxylic acid amide

Refernces

• 1、 -. "SUBSTITUTED OXOPYRIDINE DERIVATIVES". Paragraph 0480; 0481; 0498; 0499; 0500. . Retrieved 2017/10/27.