Clauszoline M

Base Information

• Chemical Name: Clauszoline M
• CAS No.: 187110-72-1
• Molecular Formula: C13H9NO3
• Molecular Weight: 227.22
• Mol file: 187110-72-1.mol

Synonyms:

Chemical Property of Clauszoline M

Chemical Property:

• PSA: 73.32000
• LogP: 2.54480

Purity/Quality:

98% ^*data from raw suppliers

ClauszolineM ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Clauszoline M

There total 11 articles about Clauszoline M which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2-benzyloxy-3-formyl-8-methoxy-9H-carbazole → clausine A (80054-00-8) + clauszoline M (187110-72-1)

Guidance literature:

With boron tribromide; In dichloromethane; at -78 - 0 ℃; Inert atmosphere;

DOI:10.1055/s-0034-1378383

Reference yield: 18.0%

clausine A (80054-00-8) → clauszoline M (187110-72-1)

Guidance literature:

With boron tribromide; In dichloromethane; at -78 - 0 ℃; for 4h; Inert atmosphere;

DOI:10.1055/s-0034-1378383

Reference yield:

2-bromoanisole (578-57-4) → clauszoline M (187110-72-1)

Guidance literature:

Multi-step reaction with 5 steps

1: caesium carbonate; palladium diacetate; XPhos / toluene / 27 h / Reflux; Inert atmosphere

2: palladium diacetate; acetic acid / 48 h / 85 °C / Inert atmosphere

3: 2,3-dicyano-5,6-dichloro-p-benzoquinone / methanol; tetrahydrofuran; water / 1.5 h / 20 °C / Inert atmosphere

4: boron tribromide / dichloromethane / -78 - 0 °C / Inert atmosphere

5: boron tribromide / dichloromethane / 4 h / -78 - 0 °C / Inert atmosphere

With palladium diacetate; boron tribromide; caesium carbonate; acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; XPhos; In tetrahydrofuran; methanol; dichloromethane; water; toluene; 1: |Buchwald-Hartwig Coupling;

DOI:10.1055/s-0034-1378383

upstream raw materials:

clausine A

2-bromoanisole

3-(benzyloxy)-4-methylaniline

Refernces