(4-Methoxyphenyl)(4-(trifluoroMethyl)phenyl)Methanone

Base Information

• Chemical Name: (4-Methoxyphenyl)(4-(trifluoroMethyl)phenyl)Methanone
• CAS No.: 6185-76-8
• Molecular Formula: C15H11F3O2
• Molecular Weight: 280.246
• Mol file: 6185-76-8.mol

Synonyms:

Chemical Property of (4-Methoxyphenyl)(4-(trifluoroMethyl)phenyl)Methanone

Chemical Property:

• PSA: 26.30000
• LogP: 3.94500

Purity/Quality:

95% ^*data from raw suppliers

4-Methoxy-4'-trifluoromethylbenzophenone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 4-Methoxy-4''-trifluoromethylbenzophenone is a useful reagent for preparing 1,2-diols.

Technology Process of (4-Methoxyphenyl)(4-(trifluoroMethyl)phenyl)Methanone

There total 54 articles about (4-Methoxyphenyl)(4-(trifluoroMethyl)phenyl)Methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-methoxyphenylboronic acid (5720-07-0) + 1-(4-(trifluoromethyl)benzoyl)pyrrolidine-2,5-dione → (4-methoxyphenyl)(4-(trifluoromethyl)phenyl)methanone (6185-76-8)

Guidance literature:

With potassium phosphate; palladium diacetate; tricyclohexylphosphine; In toluene; at 110 ℃; for 4h; Inert atmosphere; Sealed tube;

DOI:10.1016/j.tetlet.2017.08.044

Reference yield: 98.0%

4-methoxyphenylboronic acid (5720-07-0) + p-trifluoromethylbenzoic acid phenyl ester (106376-16-3) → (4-methoxyphenyl)(4-(trifluoromethyl)phenyl)methanone (6185-76-8)

Guidance literature:

With [(η³-1-^tBu-indenyl)Pd(1,3-bis(2,6-diisopropylphenyl)-1,3-dihydro-2H-imidazol-2-ylidene)(Cl)]; potassium carbonate; In tetrahydrofuran; at 23 ℃; for 15h;

DOI:10.1039/c7sc02692g

Reference yield: 98.0%

tert-butyl (4-methoxylbenzoyl)(phenyl) carbamate + 4-trifluoromethylphenylboronic acid (128796-39-4) → (4-methoxyphenyl)(4-(trifluoromethyl)phenyl)methanone (6185-76-8)

Guidance literature:

With (3-phenylallyl)(chloro)-[1,3-bis(2,6-diisopropylphenyl)-4,5-dihydroimidazol-2-ylidene]palladium(II); water; potassium carbonate; In 2-methyltetrahydrofuran; at 23 ℃; for 15h; chemoselective reaction; Inert atmosphere; Schlenk technique; Green chemistry;

DOI:10.1002/adsc.201901188

upstream raw materials:

4-trifluoromethyl-phenyl acetyl chloride

methoxybenzene

p-trifluoromethylphenyl bromide

4-methoxy-benzoyl chloride

Downstream raw materials:

1-methoxy-4-((4-(trifluoromethyl)phenyl)ethynyl)benzene

1-(2,2-difluoro-1-(4-(trifluoromethyl)phenyl)vinyl)-4-methoxybenzene

α-(4-methoxyphenyl)(4-trifluoromethyl)benzyl alcohol

[1-(4-Methoxy-phenyl)-1-(4-trifluoromethyl-phenyl)-meth-(Z)-ylidene]-hydrazine

Refernces

• 1、 Huang, Ming-Yao,Li, Xiao-Yu,Su, Yu-Xuan,Yang, Liang-Liang,Zhao, Yu-Tao,Zhu, Shou-Fei. "Dirhodium-Catalyzed Enantioselective B?H Bond Insertion of gem-Diaryl Carbenes: Efficient Access to gem-Diarylmethine Boranes". supporting information. p. 24214 - 24219. Retrieved 2021/10/07.
• 2、 Dale, Harvey J. A.,Nottingham, Chris,Poree, Carl,Lloyd-Jones, Guy C.. "Systematic Evaluation of 1,2-Migratory Aptitude in Alkylidene Carbenes". . p. 2097 - 2107. Retrieved 2021/02/01.