3-Bromo-2-chloropyridine

Base Information

• Chemical Name: 3-Bromo-2-chloropyridine
• CAS No.: 52200-48-3
• Molecular Formula: C5H3BrClN
• Molecular Weight: 192.443
• Hs Code.: 29339900
• European Community (EC) Number: 629-254-6
• DSSTox Substance ID: DTXSID40351220
• Nikkaji Number: J1.272.612K
• Wikidata: Q72453376
• Mol file: 52200-48-3.mol

Synonyms:3-Bromo-2-chloropyridine;52200-48-3;2-Chloro-3-bromopyridine;PYRIDINE, 3-BROMO-2-CHLORO-;MFCD00234007;3-bromo-2-chloro-pyridine;2-Chloro-3-Bromo Pyridine;2-chloro-bromopyridine;3-Bromo-2-chlorolpyridine;3-bromo-2- chloropyridine;SCHEMBL122934;HDYNIWBNWMFBDO-UHFFFAOYSA-;DTXSID40351220;3-Bromo-2-chloropyridine, 98%;BCP26359;CS-B1311;BBL101501;CL0158;STL555297;AKOS000272820;AC-7016;PB33875;PS-5357;BP-10118;SY004419;AM20070023;B2328;FT-0615137;EN300-54306;2-hydroxy-11H-benzo[a]carbazole-3-carboxylicacid;AC-907/25004333;J-511855;J-511919;F3099-7216;Z808600354

Chemical Property of 3-Bromo-2-chloropyridine

Chemical Property:

• Appearance/Colour: yellow Long needles
• Vapor Pressure: 0.173mmHg at 25°C
• Melting Point: 54-57 °C(lit.)
• Refractive Index: 1.581
• Boiling Point: 219.8 °C at 760 mmHg
• PKA: -0.63±0.10(Predicted)
• Flash Point: 86.8 °C
• PSA: 12.89000
• Density: 1.736 g/cm³
• LogP: 2.49750
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 190.91374
• Heavy Atom Count: 8
• Complexity: 78.8

Purity/Quality:

99% ^*data from raw suppliers

3-Bromo-2-chloropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=C(N=C1)Cl)Br
• Uses: 3-Bromo-2-chloropyridine may be used to synthesize:acetylenic dipyridone3-ethynyl-2-(phenylmethoxy)-pyridinenemertellineortho-chlorodiheteroarylamine4 or 2-chloro-N-(2,3,7-trimethylbenzo[b]thien-6-yl)pyridin-3-amine

Technology Process of 3-Bromo-2-chloropyridine

There total 13 articles about 3-Bromo-2-chloropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-chloro-3-(trimethylsilyl)pyridine (77332-76-4) → 3-bromo-2-chloropyridine (52200-48-3)

Guidance literature:

With bromine; In tetrachloromethane; for 75h; Heating;

DOI:10.1002/ejoc.200390215

Reference yield: 90.0%

3-bromo-pyridin-2-ol (13466-43-8) → 3-bromo-2-chloropyridine (52200-48-3)

Guidance literature:

With trichlorophosphate; at 140 ℃; for 2h; Autoclave; neat (no solvent);

DOI:10.3390/molecules17044533

Reference yield: 83.0%

3-bromopicolinic acid (30683-23-9) → 3-bromo-2-chloropyridine (52200-48-3)

Guidance literature:

With tert-butylhypochlorite; dichloromethane; sodium hydrogencarbonate; at 60 ℃; for 20h; Green chemistry;

DOI:10.1039/c9gc02407g

upstream raw materials:

2-chloropyridine

3-bromopyridine N-oxide

3-Bromo-2-methoxypyridine

2-chloro-3-aminopyridine

Downstream raw materials:

3-Brom-2-(4-methyl-1-piperazinyl)pyridin

2-chloropyridine

chloro-2 bromo-4 butyl-3 pyridine

2-bromo-pyridine

Refernces

• 1、 -. "PROCESS FOR PREPARING A COMPOUND BY A NOVEL SANDMEYER-LIKE REACTION USING A NITROXIDE RADICAL COMPOUND AS A REACTION CATALYST". Paragraph 0229; 0230. . Retrieved 2013/06/26.
• 2、 Cornella, Josep,Rosillo-Lopez, Martin,Larrosa, Igor. "A novel mode of reactivity for gold(I): The decarboxylative activation of (hetero)aromatic carboxylic acids". supporting information; experimental part. p. 1359 - 1366. Retrieved 2011/06/26.