Ethanone, 1-(6-broMo-1H-indazol-1-yl)-

Base Information

• Chemical Name: Ethanone, 1-(6-broMo-1H-indazol-1-yl)-
• CAS No.: 651780-33-5
• Molecular Formula: C₉H₇BrN₂O
• Molecular Weight: 239.071
• Mol file: 651780-33-5.mol

Synonyms:1-ACETYL-6-BROMO-1H-INDAZOLE;1H-Indazole,1-acetyl-6-bromo;

Chemical Property of Ethanone, 1-(6-broMo-1H-indazol-1-yl)-

Chemical Property:

• PSA: 34.89000
• LogP: 2.45890

Purity/Quality:

More than 98% ^*data from raw suppliers

1-(6-Bromo-indazol-1-yl)-ethanone 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanone, 1-(6-broMo-1H-indazol-1-yl)-

There total 3 articles about Ethanone, 1-(6-broMo-1H-indazol-1-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

6-bromo-1H-indazole (79762-54-2) + acetic anhydride (108-24-7) → 1-(6-bromo-1H-indazol-1-yl)ethanone (651780-33-5)

Guidance literature:

for 2h; Reflux;

DOI:10.1055/s-0028-1087922

Reference yield: 81.0%

5-bromo-2-methylaniline (39478-78-9) + acetic anhydride (108-24-7) + isopentyl nitrite (110-46-3) → 1-(6-bromo-1H-indazol-1-yl)ethanone (651780-33-5)

Guidance literature:

5-bromo-2-methylaniline; acetic anhydride; In chloroform; at 0 - 5 ℃;

acetic anhydride; isopentyl nitrite; With potassium acetate; In chloroform; Heating / reflux;

With sodium hydrogencarbonate; In chloroform; water; pH=7;

Reference yield:

acetic anhydride (108-24-7) + 4-Bromo-2-methylaniline (583-75-5) → 1-(6-bromo-1H-indazol-1-yl)ethanone (651780-33-5)

Guidance literature:

acetic anhydride; 4-Bromo-2-methylaniline; With potassium acetate; In chloroform; at 55 ℃; for 5h;

With tert.-butylnitrite; 18-crown-6 ether; In chloroform; at 55 ℃; for 21h;

upstream raw materials:

acetic anhydride

4-Bromo-2-methylaniline

5-bromo-2-methylaniline

isopentyl nitrite

Refernces

• 1、 -. "6' SUBSTITUTED COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY". Page/Page column 34; 35. . Retrieved 2008/12/08.