2-Bromoacrylamide

Base Information

• Chemical Name: 2-Bromoacrylamide
• CAS No.: 70321-36-7
• Molecular Formula: C3H4BrNO
• Molecular Weight: 149.975
• Hs Code.: 2924199090
• European Community (EC) Number: 891-335-9
• DSSTox Substance ID: DTXSID50550666
• Nikkaji Number: J471.579I
• Wikidata: Q82430091
• Mol file: 70321-36-7.mol

Synonyms:2-Bromoacrylamide;70321-36-7;2-Bromoprop-2-enamide;2-bromo-2-propenamide;2-Propenamide, 2-bromo-;alpha-bromoacrylamide;2-bromanylprop-2-enamide;SCHEMBL2220156;DTXSID50550666;2-Bromopropenamide, 98% (CP);AKOS006284945;EN300-7571398;A830809

Chemical Property of 2-Bromoacrylamide

Chemical Property:

• PSA: 43.09000
• LogP: 1.08060
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 148.94763
• Heavy Atom Count: 6
• Complexity: 88.8

Purity/Quality:

98% ^*data from raw suppliers

2-Bromoacrylamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C=C(C(=O)N)Br

Technology Process of 2-Bromoacrylamide

There total 1 articles about 2-Bromoacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,3-dibromopropionamide (15102-42-8) → 2-bromoacrylic acid amide (70321-36-7)

Guidance literature:

With triethylamine; In diethyl ether; for 80h; Reflux;

DOI:10.1021/acs.joc.8b02012

Reference yield: 85.0%

2-(azidomethyl)-1,3-difluorobenzene (106308-60-5) + 2-bromoacrylic acid amide (70321-36-7) → rufinamide (106308-44-5)

Guidance literature:

With trifluorormethanesulfonic acid; In acetonitrile; at -40 ℃; for 2h;

Reference yield: 25.25%

2-bromoacrylic acid amide (70321-36-7) + triphenylphosphine (603-35-0) → 3-(triphenylphosphonio)propionitrile bromide (5032-74-6) + Triphenylphosphine oxide (791-28-6)

Guidance literature:

In acetonitrile; for 20h; Reflux;

DOI:10.1134/S1070363209040148

upstream raw materials:

2,3-dibromopropionamide

Downstream raw materials:

3-(triphenylphosphonio)propionitrile bromide

Triphenylphosphine oxide

rufinamide

Refernces

• 1、 Khachikyan,Tovmasyan,Indzhikyan. "Reaction of amides of 2,3-dibromopropionic and 2-bromoacrylic acids with pyridine and triphenylphosphine". experimental part. p. 759 - 761. Retrieved 2009/09/26.