2-IsobutyraMido Guanosine 2',3',5'-Tris(isobutanoate)

Base Information

• Chemical Name: 2-IsobutyraMido Guanosine 2',3',5'-Tris(isobutanoate)
• CAS No.: 70337-80-3
• Molecular Formula: C26H37N5O9
• Molecular Weight: 563.608
• Mol file: 70337-80-3.mol

Synonyms:N2-isobutyryl-2',3',5'-tri-O-isobutyrylguanosine;N2,2',3',5'-triisobutyroylguanosine;2-N-isobutyryl-2',3',5'-tri-O-isobutyrylguanosine;N2,2',3',5'-tetraisobutyrylguanosine;N2,2',3',5'-Tetraisobutyroylguanosin;N2,2',3',5'-tetra-O-isobutyroyl-guanosine;

Chemical Property of 2-IsobutyraMido Guanosine 2',3',5'-Tris(isobutanoate)

Chemical Property:

• PSA: 184.55000
• LogP: 3.00810
• Solubility.: Chloroform, DMSO, Methanol

Purity/Quality:

97% ^*data from raw suppliers

2-IsobutyramidoGuanosine2’,3’,5’-Tris(isobutanoate) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-IsobutyraMido Guanosine 2',3',5'-Tris(isobutanoate)

There total 5 articles about 2-IsobutyraMido Guanosine 2',3',5'-Tris(isobutanoate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-Methylpropionic anhydride (97-72-3) + G (118-00-3) → N2-(2-methylpropanoyl)-2',3',5'-tris-O-(2-methylpropanoyl)guanosine (70337-80-3)

Guidance literature:

In pyridine; at 110 ℃; for 20h;

Reference yield: 89.0%

2-Methylpropionic anhydride (97-72-3) + guanosine (118-00-3) → N2,2',3',5'-tetraisobutyrylguanosine (70337-80-3)

Guidance literature:

With pyridine; for 10h; Heating;

Reference yield: 81.0%

N2,2',3',5'-tetraisobutyryl-O6-p-nitrophenylethylguanosine (86148-74-5) → N2-(2-methylpropanoyl)-2',3',5'-tris-O-(2-methylpropanoyl)guanosine (70337-80-3)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In pyridine; for 3h; Ambient temperature;

DOI:10.1016/0040-4020(84)85103-0

upstream raw materials:

2-Methylpropionic anhydride

G

N²,2',3',5'-tetraisobutyryl-O⁶-p-nitrophenylethylguanosine

isobutyryl chloride

Downstream raw materials:

N²-isobutyryl-2',3',5'-tri-O-benzoylguanosine

C₂₈H₂₇N₅O₈

N²-isobutyryl-3',5'-di-O-benzoylguanosine

N²-isobutyryl-O⁶-<2-(4-nitrophenyl)ethyl>guanosine

Refernces

• 1、 Nishino, Shigeyoshi,Takamura, Hatsuko,Ishido, Yoshiharu. "REGIOSELECTIVE PROTECTION OF CARBOHYDRATE DERIVATIVES. PART. 20. SIMPLE, EFFICIENT 2'-O-DEACYLATION OF FULLY ACYLATED PURINE AND PYRIMIDINE RIBONUCLEOSIDES THROUGH tert-BUTOXIDE". . p. 1995 - 2004. Retrieved 2007/10/02.
• 2、 Trichtinger, Thomas,Charubala, Ramamurthy,Pfleiderer, Wolfgang. "SYNTHESIS OF O6-p-NITROPHENYLETHYL GUANOSINE AND 2'-DEOXYGUANOSINE DERIVATIVES". . p. 711 - 714. Retrieved 2007/10/02.