4-(1-Piperidinyl)-2-butanol

Base Information

• Chemical Name: 4-(1-Piperidinyl)-2-butanol
• CAS No.: 71648-40-3
• Molecular Formula: C9H19NO
• Molecular Weight: 157.256
• DSSTox Substance ID: DTXSID701307406
• Nikkaji Number: J2.840.882J
• Mol file: 71648-40-3.mol

Synonyms:71648-40-3;4-(1-piperidinyl)-2-butanol;SCHEMBL1455583;alpha-Methyl-1-piperidinepropanol;ZXAPAKFRWAWSKS-UHFFFAOYSA-N;DTXSID701307406;AKOS011032857

Chemical Property of 4-(1-Piperidinyl)-2-butanol

Chemical Property:

• PSA: 23.47000
• LogP: 1.18110
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 157.146664230
• Heavy Atom Count: 11
• Complexity: 99.7

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(CCN1CCCCC1)O

Technology Process of 4-(1-Piperidinyl)-2-butanol

There total 1 articles about 4-(1-Piperidinyl)-2-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(but-3-en-1-yl)piperidine (4088-34-0) + triethylamine-borane (1722-26-5) → 1-butyl-piperidine (4945-48-6) + 4-(piperidin-1-yl)butan-2-ol (71648-40-3) + 4-piperidin-1-yl-butan-1-ol (4672-11-1) + 1-(1-piperidyl)-2-butanol (3140-33-8)

Guidance literature:

With hydrogenchloride; sodium hydroxide; dihydrogen peroxide; Yield given. Multistep reaction. Further byproducts given. Title compound not separated from byproducts; 1. reflux of INO 940 and 950 in nitrogen atmosphere 2. acetone and aq. HCl, reflux 15 min 3. H₂O, THF, reflux 1 h;

Reference yield: 58.0%

4-(piperidin-1-yl)butan-2-ol (71648-40-3) + 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carbonyl chloride (51950-71-1) → 1-methyl-3-(N-piperidino)-propyl 3-methylflavone-8-carboxylate

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 - 25 ℃;

upstream raw materials:

1-(but-3-en-1-yl)piperidine

triethylamine-borane

Refernces