6-Methyl-2,4-diphenylquinoline

Base Information

• Chemical Name: 6-Methyl-2,4-diphenylquinoline
• CAS No.: 73402-92-3
• Molecular Formula: C22H17N
• Molecular Weight: 295.384
• DSSTox Substance ID: DTXSID00389201
• Nikkaji Number: J1.835.966I
• Mol file: 73402-92-3.mol

Synonyms:6-methyl-2,4-diphenylquinoline;73402-92-3;2,4-Diphenyl-6-methylquinoline;6-Methyl-2,4-diphenyl-quinoline;Oprea1_270069;Oprea1_503730;SCHEMBL18698068;DTXSID00389201;AKOS000639231;FT-0753410;Z57110954

Chemical Property of 6-Methyl-2,4-diphenylquinoline

Chemical Property:

• XLogP3: 5.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 295.136099547
• Heavy Atom Count: 23
• Complexity: 366

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC2=C(C=C1)N=C(C=C2C3=CC=CC=C3)C4=CC=CC=C4

Technology Process of 6-Methyl-2,4-diphenylquinoline

There total 55 articles about 6-Methyl-2,4-diphenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-methyl-2-((E)-1,3-diphenylallyl)benzenamine (1357475-94-5) → 2,4-diphenyl-6-methylquinoline (73402-92-3)

Guidance literature:

With C₁₀H₁₇N₂O₂⁽¹⁺⁾*Cl₄Fe^(1-); In neat liquid; at 100 ℃; for 48h;

DOI:10.1002/adsc.201600315

Reference yield: 98.2%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + meta-bromotoluene (591-17-3) + benzonitrile (100-47-0) → 2,4-diphenyl-6-methylquinoline (73402-92-3)

Guidance literature:

With N-n-butyl-N-methylpiperidine bis(trifluoromethanesulfonyl)imide salt; acetylferrocene; H₂SiEt₂; at 50 ℃; for 10h; Reagent/catalyst;

Reference yield: 96.0%

benzaldehyde (100-52-7) + p-toluidine (106-49-0,12221-03-3) + acetophenone (98-86-2) → 2,4-diphenyl-6-methylquinoline (73402-92-3)

Guidance literature:

With trifluorormethanesulfonic acid; silver trifluoromethanesulfonate; In toluene; at 120 ℃; for 24h;

upstream raw materials:

styrene

(E)-N-benzylidene-4-toluidine

3-p-tolyl-4,6-diphenyl-2-oxo-1,3-diazabicyclo<2,2,0>hex-5-ene

4,6-diphenyl-3-(p-tolyl)-1,3-diazabicyclo<2.2.0>hex-5-en-2-one

Refernces

• 1、 Di, Jia-Qi,Ma, Cui-Ting,Xiao, Song-Tao,Zhang, Zhan-Hui. "MOF-5 as a highly efficient and recyclable catalyst for one pot synthesis of 2,4-disubstituted quinoline derivatives". . p. 8614 - 8620. Retrieved 2020/06/09.
• 2、 Guo, Fu-Hu,Lu, Hai-Long,Quan, Zheng-Jun,Wang, Tong-Lin,Wang, Xi-Cun. "Palladium-Catalyzed/Copper-Mediated Desulfurization and Aryl- ation of Quinoline-2-(1 H)-thione for Rapid Access to Quinoline Derivatives". supporting information. p. 893 - 900. Retrieved 2020/03/13.