Morphinan-8-one,6,7-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5a)- (9CI)

Base Information

• Chemical Name: Morphinan-8-one,6,7-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5a)- (9CI)
• CAS No.: 94713-16-3
• Molecular Formula: C18H19 N O3
• Molecular Weight: 297.354
• Mol file: 94713-16-3.mol

Synonyms:Pseudocodeinone(7CI)

Chemical Property of Morphinan-8-one,6,7-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5a)- (9CI)

Chemical Property:

• Boiling Point: 436.3°Cat760mmHg
• Flash Point: 217.7°C
• PSA: 38.77000
• Density: 1.34g/cm³
• LogP: 1.64720

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Morphinan-8-one,6,7-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5a)- (9CI)

There total 15 articles about Morphinan-8-one,6,7-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5a)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Pseudocodein (509-55-7) → 4,5-epoxy-3-methoxy-17-methyl-morphin-6-en-8-one (94713-16-3)

Guidance literature:

With chromium(III) oxide; sulfuric acid;

Reference yield:

pseudocodeine (466-96-6) → 4,5-epoxy-3-methoxy-17-methyl-morphin-6-en-8-one (94713-16-3)

Guidance literature:

With chromium(III) oxide; sulfuric acid;

Reference yield:

14-hydroxycodeinone (508-54-3) → 4,5α-epoxy-3-methoxy-17-methyl-(14ξ)-morphin-6-en-8-one (94713-16-3)

Guidance literature:

Multi-step reaction with 9 steps

1: NaBH₄ / dioxane

2: pyridine

3: aq. acetic acid / Heating

5: methanol / Heating

6: (i) aq. AcOH, (ii) /BRN= 385737/

7: aq. KOH / ethanol

8: MnO₂ / CHCl₃

9: H₂, aq. HCl / PtO₂ / acetic acid

With hydrogenchloride; manganese(IV) oxide; potassium hydroxide; sodium tetrahydroborate; hydrogen; platinum(IV) oxide; In 1,4-dioxane; pyridine; methanol; ethanol; chloroform; acetic acid;

DOI:10.1039/jr9600000773

upstream raw materials:

Pseudocodein

pseudocodeine

4,5α-epoxy-14-hydroxy-3-methoxy-17-methyl-morphin-6-en-8-one

4,5α-epoxy-3-methoxy-17-methyl-morphinane-8α,14-diol

Downstream raw materials:

(2-hydroxyethyl)(methyl)amine

1,5-diacetoxy-4-[2-(acetyl-methyl-amino)-ethyl]-6-methoxy-phenanthrene