Methanesulfonic acid, trifluoro-, 2-methoxy-6-methylphenyl ester

Base Information

• Chemical Name: Methanesulfonic acid, trifluoro-, 2-methoxy-6-methylphenyl ester
• CAS No.: 863727-67-7
• Molecular Formula: C9H9F3O4S
• Molecular Weight: 270.229
• Mol file: 863727-67-7.mol

Synonyms:

Chemical Property of Methanesulfonic acid, trifluoro-, 2-methoxy-6-methylphenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methanesulfonic acid, trifluoro-, 2-methoxy-6-methylphenyl ester

There total 2 articles about Methanesulfonic acid, trifluoro-, 2-methoxy-6-methylphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.4%

trifluoromethylsulfonic anhydride (358-23-6) + 2-methyl-6-methoxyphenol (2896-67-5) → 2-methoxy-6-methylphenyl trifluoromethanesulfonate (863727-67-7)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield: 74.0%

trifluoromethylsulfonic anhydride (358-23-6) + 1,2-dimethoxy-3-methylbenzene (4463-33-6) → 2-methoxy-6-methylphenyl trifluoromethanesulfonate (863727-67-7)

Guidance literature:

1,2-dimethoxy-3-methylbenzene; With niobium pentachloride; In 1,2-dichloro-ethane; for 1h; Heating;

trifluoromethylsulfonic anhydride; With pyridine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1002/ejoc.200500502

Reference yield: 97.0%

2-methoxy-6-methylphenyl trifluoromethanesulfonate (863727-67-7) + benzophenone hydrazone (5350-57-2) → diphenylmethanone (2-methoxy-6-methylphenyl)hydrazone

Guidance literature:

With BINAP; caesium carbonate; palladium diacetate; In toluene; at 100 ℃; for 16h;

upstream raw materials:

trifluoromethylsulfonic anhydride

1,2-dimethoxy-3-methylbenzene

2-methyl-6-methoxyphenol

Downstream raw materials:

1-methoxy-3-methyl-benzene

Refernces

• 1、 Sudo, Yukinori,Arai, Shigeru,Nishida, Atsushi. "Facile and regioselective dealkylation of alkyl aryl ethers using niobium(V) pentachloride". . p. 752 - 758. Retrieved 2007/10/03.